Results 151 to 160 of about 879,101 (311)

Computed Tomography Findings of Pulmonary Lymphoma in a Dog and Two Cats. [PDF]

Vet Med Sci
Tanaka T, Wada Y, Kusaka T, Tomihari M, Hasegawa T.   +4 more
europepmc   +1 more source

DTX3L Inhibits the EMT, Metastasis, and Stem‐Like Features of Gastric Cancer Through Promoting GSK‐3β Dependent SNAI1 Decay

Advanced Science, EarlyView.
This research identifies DTX3L as a critical tumor suppressor that inhibits epithelial‐mesenchymal transition (EMT), invasion and metastasis in gastric cancer. By functioning as an E3 ubiquitin ligase, DTX3L targets the master EMT regulator SNAI1 for GSK‐3β‐dependent proteasomal degradation.
Yang Chen, Zhen Li, Jiajia Shen, Jingyu Lin, Xiaoli Zhao, Rui Zhang, Ying Han, Zhen Wang   +7 more
wiley   +1 more source

P1192: ANTI-PD-1 ANTIBODY (TISLELIZUMAB) COMBINED WITH R-CHOP FOR THE TREATMENT OF PREVIOUSLY UNTREATED PRIMARY MEDIASTINAL B-CELL LYMPHOMA: A PROSPENTIVE PHASE II STUDY

HemaSphere, 2023
Wu Mei, Zhu Lin, LI Shan, Tu Erde Jia Erbao, Wang Shanshan, Liang Xiao, Hu Xin, Guo LI, A Dili Abulikemujiang, Maimaitirexiati Xianmusiya, Ren Ruirui, Wen Shujuan   +11 more
doaj   +1 more source

Bioorthogonal Fluorogenic Reporters for Noninvasive Imaging and Urinalysis of Immunotherapeutic Response in Renal Cell Carcinoma

Advanced Science, EarlyView.
This study reported renal‐clearable bio‐orthogonal near‐infrared fluorogenic probes (BGRs) that specifically imaging and urinalysis of granzyme B for dynamic evaluation of RCC immunotherapy. BGRs not only differentiate immunotherapeutic responses in orthotopic RCC mice, but also enable sensitive optical urinalysis of granzyme B in clinical specimens ...
Xingyue Yang, Baoshuai Liang, Liangmin Fu, Weiliang Deng, Yuyan Jiang, Weiping Xu, Jinwei Chen, Ya Zhou, Ke Wu, Jiaguo Huang   +9 more
wiley   +1 more source

PB2333: CAR-T CELL THERAPY IS A EXCELLENT STRATEGY FOR R/R B-NHL

HemaSphere, 2023
Liu Rui, Fan Yang, Fei Xue, Hui Shi, Peihao Zheng, Lixia MA, Shaomei Feng, Yuelu Guo, Teng Xu, Zhonghua Fu, Biping Deng, Xiaoyan Ke, Kai Hu   +12 more
doaj   +1 more source

Tumor‐Induced Splenic Remodeling: Mechanisms of Systemic Immunosuppression and Emerging Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley   +1 more source

Reprogramming Antitumor Immunity: NK Cell Strategies to Navigate the Immunosuppressive Tumor Microenvironment

Advanced Science, EarlyView.
ABSTRACT Tumor immune escape is a major barrier to durable cancer immunotherapy, as advanced malignancies create a tumor microenvironment (TME) that preferentially exhausts and disables T cell responses. While most approved cell therapies are T cell‐based, this limitation motivates the exploration of an alternative effector cell platform.
Tereza Kochs, Pranay Nath, Alice Chen, Rizwan Romee, Andreia Maia   +4 more
wiley   +1 more source

Hematolymphoid neoplasms involving the breast: A single institution clinicopathologic study of 59 patients. [PDF]

Ann Hematol
Vickery J, Peerenboom R, Siddiqui F, Joy JA, Prabu SS, Arber DA, Gurbuxani S, Biernacka A, Venkataraman G.   +8 more
europepmc   +1 more source

Discovery of a Potent Fluorescence Polarization Probe for Identifying USP1 Allosteric Inhibitors

Advanced Science, EarlyView.
This study presents the first ubiquitin‐specific protease 1 (USP1) allosteric fluoroprobe and fluorescence polarization assay, enabling the differentiation of allosteric and catalytic site inhibitors. Further, a novel class of tetrahydroisoquinoline‐based USP1 inhibitors is designed, with compound 14a (USP1 IC50 = 29.9 nM) showing strong selectivity ...
Jiawei Cheng, Peipei Wang, Pengfei Wang, Jiamin Wang, Baiyang Li, Daqing Fang, Jian He, Xiaobei Hu, Weijuan Kan, Yubo Zhou, Chunpu Li, Jia Li, Hong Liu   +12 more
wiley   +1 more source

A prospective study of prophylactic dexamethasone with glofitamab in relapsed/refractory large B-cell lymphoma

Blood Neoplasia
J. Erika Haydu, Matthew M. Lei, Robert A. Redd, Jeffrey A. Barnes, Elijah P. Darnell, Ephraim P. Hochberg, P. Connor Johnson, Ronald W. Takvorian, James I. Weitzman, Elliot C. Woods, Tiffany L. Hurvitz, Courtney D. Lafranchi, Patricia Livingstone, Julia M. Lynch, Emily N. Patterson, Jack E. Malespini, Brianne M. McGree, Alexa O. Santilli, Katherine A. Thorp, Maryanne M. Sherburne, Lindsey B. Wardrop, Uvette Y. Lou, Mark N. Sorial, Catherine Cho, Josie Ford, Ronnie Nemac, Jacob D. Soumerai, Jeremy S. Abramson   +27 more
doaj   +1 more source