Results 231 to 240 of about 606,957 (319)

Differential Immune Cell Infiltration in Eosinophilic and Non‐Eosinophilic CRS: Correlations With Clinical, Endoscopic, and Radiological Findings

open access: yesInternational Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background The pathogenesis of inflammation in eosinophilic chronic rhinosinusitis (ECRS) and non‐eosinophilic chronic rhinosinusitis (NECRS) remains poorly understood. This study aimed to assess immune cell infiltration within the sinonasal microenvironment in these conditions.
Katarzyna Czerwaty   +5 more
wiley   +1 more source

Chemical Process Development in the Pharmaceutical Industry in Europe—Insights and Perspectives from Industry Scientists

open access: yesAngewandte Chemie, EarlyView.
What are the tasks of chemical process development in the pharmaceutical industry? What are trends and challenges? This Scientific Perspective written by members of the European pharmaceutical industry introduces key concepts of drug development and key drivers for the future of chemical process development.
Joachim Krueger   +12 more
wiley   +2 more sources

Impact of Age on Biology, Presentation and Outcomes in Marginal Zone Lymphoma: Results From a Multicenter Cohort Study. [PDF]

open access: yesHematol Oncol
Torka P   +16 more
europepmc   +1 more source

Beyond Structure: Methylation Fine‐Tunes Stability and Folding Kinetics of bcl2Mid G‐Quadruplex

open access: yesAngewandte Chemie, EarlyView.
The introduction of a single 5‐methylcytosine into a G‐rich sequence originating from the B‐cell lymphoma 2 (BCL2) gene promoter affects both the folding kinetics and thermodynamics of the two G4 structures and thus plays a crucial role in regulating G4 folding pathways, which has significant implications for the control of gene expression.
Nataša Medved   +5 more
wiley   +2 more sources

Development and validation of BCG vaccine‐induced novel granulomatous liver injury preclinical animal model

open access: yesAnimal Models and Experimental Medicine, EarlyView.
The study successfully developed and validated a granulomatous liver injury model using a high‐dose BCG vaccine, simulating hepatic tuberculosis and autoimmune granulomatous liver diseases. Pharmacokinetic analysis examined the metabolic behavior of first‐line antitubercular drugs (isoniazid and rifampicin) and their main metabolites under conditions ...
Swati Sharma   +8 more
wiley   +1 more source

Recent Advances in Cancer Cell Membrane‐Based Nanoparticles and Cancer Cell‐Derived Small Extracellular Vesicles as Drug Delivery Platforms

open access: yesAdvanced NanoBiomed Research, EarlyView.
Cancer cell membrane‐based nanoparticles (CCM‐NPs) and cancer cell‐derived small extracellular vesicles (CsEVs) are emerging as promising drug delivery systems for targeted cancer treatment. Advances in nanotechnology have paved the way for innovative drug delivery systems that enhance the effectiveness of cancer treatment.
Wei Zhang   +4 more
wiley   +1 more source

An Ulcerated Nodule on the Toe in an Elderly Patient: A Quiz. [PDF]

open access: yesActa Derm Venereol
Liu Z, Zhang Q, Chen L, Huang Q.
europepmc   +1 more source

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