Results 281 to 290 of about 97,922 (330)
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Lyophilization Process Design Space
Journal of Pharmaceutical Sciences, 2013The application of key elements of quality by design (QbD), such as risk assessment, process analytical technology, and design space, is discussed widely as it relates to freeze-drying process design and development. However, this commentary focuses on constructing the Design and Control Space, particularly for the primary drying step of the freeze ...
Sajal Manubhai, Patel, Michael J, Pikal
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Lyophilization of Human Cytomegaloviruses
Pathobiology, 1971Lyophilization of CMV strains was performed at O°C or at 25°C with or without the addition of Parke, Davis additive. Dried viral preparations were thereafter stored at 4°C or at -20°C and tested for infectivity. The results of experiments have shown that CMV can be lyophilized at O°C with little or no loss of infectivity.
M, Jung, U, Krech
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Lyophilized platelets: continued development
Transfusion Science, 2000In our initial investigation of functionality of platelets freeze-dried after stabilization with 1.8% paraformaldehyde, we found that the rehydrated cells were morphologically intact and retained adhesive and procoagulant properties. Further testing of fixed, washed freeze-dried platelets has demonstrated the physiologic nature of their adhesion in ...
A P, Bode, M S, Read
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Cross-contamination during lyophilization
Cryobiology, 1982Abstract Cross-contamination during lyophilization was studied in two freeze-dryers. Suspensions of test organisms (Pseudomonas aeruginosa and Proteus mirabilis) sensitive to colistin and neomycin, respectively, were dispensed into vials, freeze-dried, and plated on an agar medium containing colistin or neomycin.
J M, Barbaree, A, Sanchez
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2003
However effective a therapeutic agent may appear during clinical trials, its full potential as a marketable product can only be assured if the material can be stored and distributed in a stabilized form. This is particularly the case with labile biologlcals, such as attenuated vaccines, especially when these products need to be transported in tropical ...
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However effective a therapeutic agent may appear during clinical trials, its full potential as a marketable product can only be assured if the material can be stored and distributed in a stabilized form. This is particularly the case with labile biologlcals, such as attenuated vaccines, especially when these products need to be transported in tropical ...
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2007
This chapter describes the methods that can be applied to successfully freeze-dry proteins. Laboratory applications are given at small scale, typified by the purification of a protein intermediate as part of the analytical characterization of a protein, and at intermediate scale, as illustrated by the pilot development of a lyophilized protein ...
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This chapter describes the methods that can be applied to successfully freeze-dry proteins. Laboratory applications are given at small scale, typified by the purification of a protein intermediate as part of the analytical characterization of a protein, and at intermediate scale, as illustrated by the pilot development of a lyophilized protein ...
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Refrigerated storage of lyophilized and rehydrated, lyophilized human red cells
Transfusion, 1993Human red cells (RBCs) were collected in CPDA‐1 and then freeze‐dried in lyoprotective solution. The lyophilized RBCs were then stored at ‐20 degrees C for 7 days. At the end of the storage period, the lyophilized RBCs were rehydrated and washed in dextrose saline.
S O, Sowemimo-Coker +3 more
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Drug Development and Industrial Pharmacy, 2018
The curcumin (CUR)-hydroxypropyl-β-cyclodextrin (HP-β-CD) inclusion complex (CUR-HP-β-CD) was prepared to erase its therapeutic restrictions of poor aqueous solubility and low oral bioavailability.
Ningli Li +9 more
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The curcumin (CUR)-hydroxypropyl-β-cyclodextrin (HP-β-CD) inclusion complex (CUR-HP-β-CD) was prepared to erase its therapeutic restrictions of poor aqueous solubility and low oral bioavailability.
Ningli Li +9 more
semanticscholar +1 more source
Survival of lyophilized yeasts
Medical Mycology, 1962Some members of the genus Candida and genus Saccharomyces are freeze-dried by a relatively new method, which is described in full. Stability of the desiccates is measured by colony counts and tested by exposure to 100°C. and long term storage at room temperature. An attempt is made to correlate the survival under both conditions.
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