Results 41 to 50 of about 9,234 (260)

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Pielęgnowanie intymności – użycie drugiej osoby gramatycznej w poezji lirycznej

Teksty Drugie, 2020
Philosophers discussing lyric poetry often focus on first personal expression as a mark of the “lyric” which has resulted in a narrow characterisation of the nature of intimacy in lyric poetry that focuses on the individual poet, poetic voice, or reader.
Karen Simecek
doaj  

A Mystic Analysis of Alda Merini’s Poetry [PDF]

پژوهش‌نامۀ انتقادی متون و برنامه‌های علوم انسانی, 2018
AldaMerini appearsamong those contemporary Italian poets translated into Persian. Merini is a poetess of great renown because her poetry leads readers to the knowledge of a world-wide aspect of literature.
Mohammad Hussein Ramezankiaei, Mahtab Alimohammadi Malayeri   +1 more
doaj  

Il meriggio nella natura Riflessioni estetiche su un’utopia poetica

Enthymema, 2013
There is a particular space-time combination in which poetry is meant to find its perfect place, its perfect happening: it’s the meridian moment, the midday spent in a locus amoenus singing and playing along with fellow-poets. It seems to be what Bachtin
Francesco Giusti
doaj   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Hypersynchrony in sarcomeric hypertrophic cardiomyopathy: description and mechanistic approach using multimodal electro-mechanical non-invasive cartography (HSYNC study)

Frontiers in Cardiovascular Medicine
BackgroundLittle is known about left ventricular (LV) sequences of contraction and electrical activation in hypertrophic cardiomyopathy (HCM). A better understanding of the underlying relation between mechanical and electrical activation may allow the ...
Patricia Réant, Patricia Réant, Patricia Réant, Patricia Réant, Patricia Réant, Guillaume Bonnet, Guillaume Bonnet, Guillaume Bonnet, Guillaume Bonnet, Guillaume Bonnet, Frédérique Dubé, Frédérique Dubé, Frédérique Dubé, Charles Massie, Charles Massie, Charles Massie, Amélie Reynaud, Matthieu Michaud, Matthieu Michaud, Matthieu Michaud, Josselin Duchateau, Josselin Duchateau, Josselin Duchateau, Stéphane Lafitte, Stéphane Lafitte, Stéphane Lafitte, Stéphane Lafitte   +26 more
doaj   +1 more source

Ontological Metaphor in Adele’s Selected Song Lyrics

Vivid: Journal of Language and Literature, 2017
This article discusses the ontological metaphor found in Adele’s songs. It aims to determine the types of ontological metaphor and their meanings. Lakoff and Johnson’s theory of conceptual metaphor is used in analyzing the data.
Bindra Gisca Maya
doaj   +1 more source