Results 311 to 320 of about 898,492 (409)

Histone modifications in the regulation of erythropoiesis. [PDF]

open access: yesAnn Med
Wu X   +7 more
europepmc   +1 more source

CPL‐Diff: A Diffusion Model for De Novo Design of Functional Peptide Sequences with Fixed Length

open access: yesAdvanced Science, EarlyView.
This study presents a diffusion model for generating functional peptide sequence lengths using mask control. The model can generate antimicrobial, antifungal, and antiviral peptides with specific lengths on demand. The model learns the structure of peptides better and generates peptides with better physicochemical properties, and the model has good ...
Zhenjie Luo   +5 more
wiley   +1 more source

Acetylation suppresses breast cancer progression by sustaining CLYBL stability. [PDF]

open access: yesJ Transl Med
Deng X   +13 more
europepmc   +1 more source

Targeting Senescence with Apigenin Improves Chemotherapeutic Efficacy and Ameliorates Age‐Related Conditions in Mice

open access: yesAdvanced Science, EarlyView.
As a plant‐derived flavonoid, apigenin directly targets PRDX6 to inhibit its PLA2 activity, blocking HSPA8 activation and disturbing its interactions with ATM and p38MAPK in senescent cells. By dampening wide spectrum expression of the SASP, apigenin prevents loss of tissue homeostasis, improves organ function, and alleviates multiple age‐related ...
Hongwei Zhang   +10 more
wiley   +1 more source

Simultaneous Monitoring of Tyrosinase and ATP in Thick Brain Tissues Using a Single Two‐Photon Fluorescent Probe

open access: yesAdvanced Science, EarlyView.
A single dual‐emission two‐photon fluorescent probe is designed for simultaneously tracking tyrosinase (TYR) and adenosine triphosphate (ATP). With the help of this probe, the intricate correlation and regulatory mechanism between TYR and ATP during oxidative stress is uncovered.
Hong Huang   +12 more
wiley   +1 more source

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

open access: yesMolecules and Cells, 2013
Jeongsoon Park   +11 more
semanticscholar   +1 more source

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