Results 381 to 390 of about 898,492 (409)

Lysine-Targeting Covalent Inhibitors.

Angewandte Chemie, 2017
Targeted covalent inhibitors have gained widespread attention in drug discovery as a validated method to circumvent acquired resistance in oncology. This strategy exploits small-molecule/protein crystal structures to design tightly binding ligands with ...
Jonathan Pettinger, Keith Jones, M. Cheeseman   +2 more
semanticscholar   +1 more source

The path of lysine to pyrrolysine

Current Opinion in Chemical Biology, 2013
Pyrrolysine is the 22nd genetically encoded amino acid. For many years, its biosynthesis has been primarily a matter for conjecture. Recently, a pathway for the synthesis of pyrrolysine from two molecules of lysine was outlined in which a radical SAM enzyme acts as a lysine mutase to generate a methylated ornithine from lysine, which is then ligated to
openaire   +2 more sources

Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing

Science, 2002
R. Cao, Liangjun Wang, Hengbin Wang, L. Xia, H. Erdjument-Bromage, P. Tempst, Richard S. Jones, Yi Zhang   +7 more
semanticscholar   +1 more source

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

Science, 2009
Chunaram Choudhary, Chanchal Kumar, Florian Gnad, M. L. Nielsen, Michael Rehman, T. Walther, J. V. Olsen, M. Mann   +7 more
semanticscholar   +1 more source

Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins

Nature, 2001
M. Lachner, D. O’Carroll, S. Rea, K. Mechtler, T. Jenuwein   +4 more
semanticscholar   +1 more source

Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain

Nature, 2001
Andrew J. Bannister, P. Zegerman, J. Partridge, E. Miska, Jean O. Thomas, R. Allshire, T. Kouzarides   +6 more
semanticscholar   +1 more source

The Chick Assay of Lysine

Biometrics, 1966
The amino-acid lysine is an important constituent of animal diets, and methods of assaying it have been widely studied (e.g. Tsien, Johnson & Liener [1957]; Ousterhout, Grau & Lundholm [1959]). The interpretation of such assays is not always easy because of the suspicion that,factors other than lysine in the test foods may be changing the food ...
openaire   +3 more sources

The diverse functions of histone lysine methylation

Nature reviews. Molecular cell biology, 2005
Cyrus Martin, Yi Zhang
semanticscholar   +1 more source

Lysine 2,3-aminomutase and the mechanism of the interconversion of lysine and beta-lysine.

Advances in enzymology and related areas of molecular biology, 1993
Perry A. Frey, George H. Reed
openaire   +3 more sources

UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites

Nature Structural & Molecular Biology, 2018
V. Akimov, Inigo Barrio-Hernandez, Sten V. F. Hansen, P. Hallenborg, A. Pedersen, Dorte B. Bekker-Jensen, M. Puglia, S. D. K. Christensen, J. Vanselow, M. Nielsen, I. Kratchmarova, C. Kelstrup, J. Olsen, B. Blagoev   +13 more
semanticscholar   +1 more source