Results 181 to 190 of about 47,347 (229)

Lysophosphatidic Acid Receptors

Molecular Pharmacology, 2000
Lysophosphatidic acid (LPA) is a simple bioactive phospholipid with diverse physiological actions on many cell types. LPA induces proliferative and/or morphological effects and has been proposed to be involved in biologically important processes including neurogenesis, myelination, angiogenesis, wound healing, and cancer progression.
J J, Contos, I, Ishii, J, Chun
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Lysophosphatidic acid: mitogen and motility factor

Biochemical Society Transactions, 2003
LPA (lysophosphatidic acid), the simplest of al glycerophospholipids, is a potent inducer of cell proliferation, migration and survival. It does so by activating its cognate G-protein-coupled receptors, four of which have been identified. LPA receptors couple to at least three distinct G-proteins and thereby activate multiple signal transduction ...
Leeuwen, F.N. van, Giepmans, B.N., Meeteren, L.A. van, Moolenaar, W.H.   +3 more
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Lysophosphatidic acid signalling

Current Opinion in Cell Biology, 1995
Lysophosphatidic acid is an intercellular phospholipid messenger that is released from platelets (and probably other cells) and evokes multiple biological responses, ranging from induction of mitogenesis to neurite retraction, by activating a specific G protein coupled receptor.
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Lysophosphatidic acid in neural signaling

NeuroReport, 2002
The physiological and pathological importance of lysophosphatidic acid (LPA) in the nervous system is underscored by its presence, as well as the expression of its receptors in neural tissues. In fact, LPA produces responses in a broad range of cell types related to the function of the nervous system.
Xiaoqin, Ye, Nobuyuki, Fukushima, Marcy A, Kingsbury, Jerold, Chun   +3 more
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Lysophosphatidic Acid and Invasion

2009
Lysophosphatidic acid (LPA) is a small, bioactive phospholipid produced by activated platelets, mesothelial cells, macrophage, endothelial cells, fibroblasts, adipocytes, and some cancer cells. It is involved in multiple cellular events of almost every mammalian cell type.
Fengqiang, Wang, David A, Fishman
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Signalling properties of lysophosphatidic acid

Trends in Pharmacological Sciences, 1993
Lysophosphatidic acid (LPA) is the simplest natural phospholipid, primarily known as a membrane component and metabolic intermediate. However, a remarkable variety of biological effects of this compound have come to light, seemingly pointing to an additional role for LPA as a signalling molecule. In this review, Marcel Durieux and Kevin Lynch integrate
M E, Durieux, K R, Lynch
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Mechanisms of lysophosphatidic acid production

Seminars in Cell & Developmental Biology, 2004
Lysophosphatidic acid is one of the most attractive phospholipid mediator with multiple biological functions and is implicated in various human diseases. In the past ten years much has been learned about the physiological roles of LPA through series of studies on LPA actions and its receptors.
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Neurotransmitter Release from Lysophosphatidic Acid-Stimulated PC12 Cells: Involvement of Lysophosphatidic Acid Receptors

Biochemical and Biophysical Research Communications, 1993
The significance of phospholipase D in metabolic regulation is being recognized. The products of phospholipase D action are phosphatidic acid and lysophosphatidic acid (LPA). Whether these lipid products exert their effect through plasma membrane receptor-mediated mechanism is not yet clear.
S, Shiono, K, Kawamoto, N, Yoshida, T, Kondo, T, Inagami   +4 more
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