Results 191 to 200 of about 47,686 (230)

Signalling properties of lysophosphatidic acid

Trends in Pharmacological Sciences, 1993
Lysophosphatidic acid (LPA) is the simplest natural phospholipid, primarily known as a membrane component and metabolic intermediate. However, a remarkable variety of biological effects of this compound have come to light, seemingly pointing to an additional role for LPA as a signalling molecule. In this review, Marcel Durieux and Kevin Lynch integrate
M E, Durieux, K R, Lynch
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Mechanisms of lysophosphatidic acid production

Seminars in Cell & Developmental Biology, 2004
Lysophosphatidic acid is one of the most attractive phospholipid mediator with multiple biological functions and is implicated in various human diseases. In the past ten years much has been learned about the physiological roles of LPA through series of studies on LPA actions and its receptors.
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Neurotransmitter Release from Lysophosphatidic Acid-Stimulated PC12 Cells: Involvement of Lysophosphatidic Acid Receptors

Biochemical and Biophysical Research Communications, 1993
The significance of phospholipase D in metabolic regulation is being recognized. The products of phospholipase D action are phosphatidic acid and lysophosphatidic acid (LPA). Whether these lipid products exert their effect through plasma membrane receptor-mediated mechanism is not yet clear.
S, Shiono, K, Kawamoto, N, Yoshida, T, Kondo, T, Inagami   +4 more
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Lysophosphatidic acid (LPA) and its receptors

Current Opinion in Pharmacology, 2009
Lysophosphatidic acid (LPA), a bioactive phospholipid, and its family of cognate G protein-coupled receptors have demonstrated roles in many biological functions in the nervous system. To date, five LPA receptors have been identified, and additional receptors may exist.
Kyoko, Noguchi, Deron, Herr, Tetsuji, Mutoh, Jerold, Chun   +3 more
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Lysophosphatidic acid: receptors, signaling and survival

Cellular and Molecular Life Sciences, 2000
Though the mitogenic activity of lysophosphatidic acid (LPA) has been well established through classical studies, its mechanism of action was long obscure. Recent identification and cloning of LPA-specific receptors has led to the elucidation of the G-proteins and signaling pathways through which this molecule functions.
J T, Swarthout, H W, Walling
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Molecular mechanisms of lysophosphatidic acid action

Progress in Lipid Research, 2003
2. The origins of LPA in biological fluids 499 2.1. Generation by phospholipase hydrolysis 499 2.2. Generation by lysophospholipase D cleavage 501 2.3.
Gabor, Tigyi, Abby L, Parrill
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Lysophosphatidic acid signaling in ovarian cancer

Journal of Receptors and Signal Transduction, 2015
Lysophosphatidic acid (LPA) is a bioactive phospholipid that is involved in signal transduction between cells. Plasma and ascites levels of LPA are increased in ovarian cancer patients even in the early stages and thus LPA is considered as a potential diagnostic marker for this disease. This review presents the current knowledge regarding LPA signaling
Anna, Jesionowska, Elzbieta, Cecerska-Heryc, Natalia, Matoszka, Barbara, Dolegowska   +3 more
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Lysophosphatidic Acid

British Journal of Pharmacology, 2006
S P H Alexander, A Mathie, J A Peters
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Multiple astrocyte responses to lysophosphatidic acids

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2002
Lysophosphatidic acid (LPA) and LPA receptors are enriched in the brain. Moreover, the levels of these receptors and ligand are modulated during brain development and injury, respectively, suggesting multiple roles for LPA in the brain. In cultured astrocytes and glioma-derived cells, LPA increases intracellular calcium concentrations and causes ...
Marion R, Steiner, Jan R, Urso, Jennifer, Klein, Sheldon M, Steiner   +3 more
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Effects of lysophosphatidic acid on melanogenesis

Chemistry and Physics of Lipids, 2004
In this study, we investigated the effects of lysophosphatidic acid (LPA) on melanogenesis in Mel-Ab cells. We found that LPA significantly attenuates melanin synthesis, and reduces the activity of tyrosinase, the rate-limiting melanogenic enzyme. Interestingly, LPA was also found to induce the activation of a 90 kDa ribosomal S6 kinase (RSK-1), which ...
Dong-Seok, Kim, Seo-Hyoung, Park, Sun-Bang, Kwon, Sang-Woong, Youn, Kyoung-Chan, Park   +4 more
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