Results 191 to 200 of about 47,347 (229)

Lysophosphatidic acid (LPA) and its receptors

Current Opinion in Pharmacology, 2009
Lysophosphatidic acid (LPA), a bioactive phospholipid, and its family of cognate G protein-coupled receptors have demonstrated roles in many biological functions in the nervous system. To date, five LPA receptors have been identified, and additional receptors may exist.
Kyoko, Noguchi, Deron, Herr, Tetsuji, Mutoh, Jerold, Chun   +3 more
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Lysophosphatidic acid: receptors, signaling and survival

Cellular and Molecular Life Sciences, 2000
Though the mitogenic activity of lysophosphatidic acid (LPA) has been well established through classical studies, its mechanism of action was long obscure. Recent identification and cloning of LPA-specific receptors has led to the elucidation of the G-proteins and signaling pathways through which this molecule functions.
J T, Swarthout, H W, Walling
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Molecular mechanisms of lysophosphatidic acid action

Progress in Lipid Research, 2003
2. The origins of LPA in biological fluids 499 2.1. Generation by phospholipase hydrolysis 499 2.2. Generation by lysophospholipase D cleavage 501 2.3.
Gabor, Tigyi, Abby L, Parrill
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Lysophosphatidic acid signaling in ovarian cancer

Journal of Receptors and Signal Transduction, 2015
Lysophosphatidic acid (LPA) is a bioactive phospholipid that is involved in signal transduction between cells. Plasma and ascites levels of LPA are increased in ovarian cancer patients even in the early stages and thus LPA is considered as a potential diagnostic marker for this disease. This review presents the current knowledge regarding LPA signaling
Anna, Jesionowska, Elzbieta, Cecerska-Heryc, Natalia, Matoszka, Barbara, Dolegowska   +3 more
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Lysophosphatidic Acid

British Journal of Pharmacology, 2006
S P H Alexander, A Mathie, J A Peters
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Multiple astrocyte responses to lysophosphatidic acids

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2002
Lysophosphatidic acid (LPA) and LPA receptors are enriched in the brain. Moreover, the levels of these receptors and ligand are modulated during brain development and injury, respectively, suggesting multiple roles for LPA in the brain. In cultured astrocytes and glioma-derived cells, LPA increases intracellular calcium concentrations and causes ...
Marion R, Steiner, Jan R, Urso, Jennifer, Klein, Sheldon M, Steiner   +3 more
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Effects of lysophosphatidic acid on melanogenesis

Chemistry and Physics of Lipids, 2004
In this study, we investigated the effects of lysophosphatidic acid (LPA) on melanogenesis in Mel-Ab cells. We found that LPA significantly attenuates melanin synthesis, and reduces the activity of tyrosinase, the rate-limiting melanogenic enzyme. Interestingly, LPA was also found to induce the activation of a 90 kDa ribosomal S6 kinase (RSK-1), which ...
Dong-Seok, Kim, Seo-Hyoung, Park, Sun-Bang, Kwon, Sang-Woong, Youn, Kyoung-Chan, Park   +4 more
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Two pathways for lysophosphatidic acid production

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2008
Lysophosphatidic acid (LPA, 1- or 2-acyl-sn-glycerol 3-phosphate) is a simple phospholipid but displays an intriguing cell biology that is mediated via interactions with G protein-coupled seven transmembrane receptors (GPCRs). So far, five GPCRs, designated LPA1-5, and, more recently, two additional GPCRs, GPR87 and P2Y5, have been identified as ...
Junken, Aoki, Asuka, Inoue, Shinichi, Okudaira   +2 more
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Lysophosphatidic acid induces osteocyte dendrite outgrowth

Biochemical and Biophysical Research Communications, 2007
Osteocytes elaborate an extensive mechanosensory network in bone matrix and communicate intercellularly via gap junctions established at dendrite termini. We developed a method to measure osteocyte dendritogenesis in vitro using a modified transwell assay and determined that the lipid growth factor lysophosphatidic acid (LPA) is a potent stimulator of ...
Sue A, Karagiosis, Norman J, Karin
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Mitogenic Action of Lysophosphatidic Acid

1991
Publisher Summary This chapter discusses the multiple biological effects of phosphatidic acid (PA) and lysophosphatidic acid (LPA), with particular emphasis on their growth factor-like activities. LPA and PA are the key intermediates in the early steps of phospholipid biosynthesis. They can exert their own biological effects. In particular, exogenous
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