Results 111 to 120 of about 158,851 (164)

Arl8b inactivates the Rab11a recycling pathway to promote LAMP1 sorting and lysosome biogenesis. [PDF]

J Cell Biol
Chouhan P, Phogat Y, Walia K, Debnath S, Choubey S, Gupta M, Tuli A, Sharma M.   +7 more
europepmc   +1 more source

Taliglucerase Alfa Reduces Amyloid-β Burden by Restoring Autophagic Pathways in a Neuronal Model of Alzheimer's Disease. [PDF]

Neurochem Res
Özkurt Ç, Köse S, Karasu Ç, Kortholt A, Kelicen-Uğur P.   +4 more
europepmc   +1 more source

Lysosome-directed targeted protein degradation technologies for overcoming cancer drug resistance: mechanisms, design principles, and therapeutic opportunities. [PDF]

Drug Deliv
Mao H, Zhang Y, Liu M, Yao Y, Peng Y, Zhou X, Huang H, Fei W, Zheng C, Ye Y.   +9 more
europepmc   +1 more source

Secretion of the HBV small surface antigen is driven by an ER autophagic pathway. [PDF]

Hepatol Commun
Cao H, Krueger E, Chen J, Yang H, Chia JJ, Beran RK, Tam J, Kornyeyev D, Holdorf MM, McNiven MA.   +9 more
europepmc   +1 more source

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Lipids and Lysosomes

Current Drug Metabolism, 2012
Lysosomes are cytoplasmic organelles delimited by a single membrane and filled with a variety of hydrolytic enzymes active at acidic pH and collectively capable to degrade the vast majority of macromolecules entering lysosomes via endocytosis, phagocytosis or autophagy.
Hamer, Isabelle, Van Beersel, Guillaume, Arnould, Thierry, Jadot, Michel   +3 more
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Lysosomal Membrane Proteomics and Biogenesis of Lysosomes

Molecular Neurobiology, 2005
This review focuses on events involved in the biogenesis of the lysosome. This organelle contains a diverse array of soluble, luminal proteins capable of digesting all the macromolecules in the cell. Altered function of lysosomes or its constituent enzymes has been implicated in a host of human pathologies, including storage diseases, cancer, and ...
Richard D, Bagshaw, Don J, Mahuran, John W, Callahan   +2 more
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Lysosomes and lysosomal cathepsins in cell death

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2012
Lysosomes are the key degradative compartments of the cell. Lysosomal cathepsins, which are enclosed in the lysosomes, help to maintain the homeostasis of the cell's metabolism by participating in the degradation of heterophagic and autophagic material. Following the targeted lysosomal membrane's destabilization, the cathepsins can be released into the
Repnik, Urška, Stoka, Veronika, Turk, Vito, Turk, Boris   +3 more
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Lysosomes, Lysosomal Enzymes, and Cancer

1992
Publisher Summary Lysosomes are membrane-enclosed cytoplasmic organelles, which posses an acidic interior that contains many hydrolytic enzymes. Their major function is in the the degradation of macromolecules, which may be cellular or foreign in origin.
M J, Boyer, I F, Tannock
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Intracellular trafficking of lysosomal proteins and lysosomes

Int. Journal of Clinical Pharmacology and Therapeutics, 2009
In the synthesis and trafficking of precursors of most lysosomal matrix proteins, the stages necessary for lysosomal delivery include the addition of phosphorylated mannose-rich oligosaccharides, binding of the modified proteins to receptors, their segregation from the secretory pathways and delivery to the endosomal pathway.
A, Hasilik, C, Wrocklage, B, Schröder
openaire   +2 more sources