Results 161 to 170 of about 180,932 (288)

[Chronobiology of lysosomes].

Voprosy meditsinskoi khimii, 1988
Circadian and seasonal alterations of lysosomes were studied in myocardium and hepatocytes of intact rabbits by means of electron microscopy and biochemical techniques. The daily-seasonal rhythm of lysosomes was related to concentration of free fatty acids in blood as well as to helio-geomagnetical activity.
openaire   +2 more sources

SPSB1 Promotes Subcutaneous Adipose Hyperplasia in Facial Port‐Wine Stains by Controlling HDAC1 Degradation and Stability Through Two Distinct Proteolytic Pathways

Advanced Science, EarlyView.
In PWS‐ASPCs, FOSL1 drives the expression of SPSB1. SPSB1, as part of the ESC complex, further binds to HDAC1 and promotes K29‐linked and K48‐linked polyubiquitination of HDAC1. These modifications facilitate the degradation of HDAC1 through the ALP and UPS pathways, respectively.
Hongrui Chen, Bin Sun, Yajing Qiu, Chen Hua, Xiaoxi Lin, Wei Gao   +5 more
wiley   +1 more source

Proteome-Level Autophagy-Lysosome Remodelling Marks Ageing in Human Dermal Fibroblasts and Nominates Hydroxytyrosol as a Candidate Nutraceutical. [PDF]

Int J Mol Sci
Cai M, Xu M.
europepmc   +1 more source

O‐GlcNAcylation Regulation of SNAP29‐Dependent Autophagy Activation Dictates Chemoresistance in Gastric Cancer

Advanced Science, EarlyView.
Model illustrating the proposed mechanism by which chemotherapy‐induced downregulation of OGT disrupts SNAP29 O‐GlcNAcylation, promoting STX17‐SNAP29‐VAMP8 SNARE complex assembly and protective autophagy, leading to chemoresistance, which in turn establishes a feedforward loop to perpetuate drug tolerance.
Liang Tang, Shaoji Zhao, Ziling Shao, Tao Luo, Baifu Peng, Yifan Liu, Jinning Ye, Jianjun Peng, Kaiyu Sun, Jianbo Xu   +9 more
wiley   +1 more source

Cytometry analysis of lysosomal membrane stability

Lysosomal dysfunction is linked to various diseases, including neurodegenerative, cardiovascular, and cancerous conditions. Damage to the lysosomal membrane, causing lysosomal membrane permeabilization (LMP), can lead to autophagy, inflammation, or cell ...
Aly, Reyad Ahmed Shaaban Mohamed
core  

Targeted Lysosomal Degradation of Extracellular and Membrane Proteins: From Receptor Hijacking to Programmable Endolysosomal Routing. [PDF]

Adv Sci (Weinh)
Liu K, Wang X, Liu X, He C, Qian D, Meng X, Zhu L.   +6 more
europepmc   +1 more source

Lysosomes And The Skin

Journal of Investigative Dermatology, 1975
Lazarus, Gerald S., Hatcher, Victor B., Levine, Norman   +2 more
openaire   +2 more sources

TLDc proteins: Stress-responsive nexus regulators of redox signaling, V-ATPase dynamics, and organellar crosstalk in neurodegeneration. [PDF]

Redox Biol
Ghufran MS, Soni P, Thomas B.
europepmc   +1 more source

Lysosomes in hepatomas [PDF]

Biochemical Journal, 1969
S, Wattiaux-De Coninck, J M, Van Dijck, H P, Morris, R, Wattiaux   +3 more
openaire   +2 more sources

ANGPTL4 Exacerbates Renal Injury in Diabetic Kidney Disease by Impairing Podocyte Lipophagy via Compromised Lysosomal Degradative Function

Advanced Science, EarlyView.
In diabetic kidney disease, elevated podocyte ANGPTL4 is linked to reduced TFEB nuclear localization and compromised lysosomal degradative function. These changes impair podocyte lipophagy and promote lipid‐droplet accumulation and podocyte injury, which may contribute to renal injury progression.
Xiaojing Liu, Shimin Jiang, Zhenkun Yang, Shunlai Shang, Jiayi Li, Guming Zou, Cheng Zhou, Wenge Li   +7 more
wiley   +1 more source