Results 201 to 210 of about 174,460 (337)

Gut Metabolite Indole‐3‐Propionic Acid Regulates Macrophage Autophagy Through PPT1 Inhibiting Aging‐Related Myocardial Fibrosis

Advanced Science, EarlyView.
IPA is an intestinal tryptophan metabolite whose effects decline with decreased heart function. Supplementing IPA can alleviate the aging‐related myocardial fibrosis through PPT1. PPT1 is a key protein localized to lysosomes, and IPA can restore macrophage autophagy function by regulating PPT1 expresssions, thereby reducing aging‐related myocardial ...
Jing Lu, Hongyan Wang, Haiyu Zhang, Jiahao Li, Hanqi Li, Qiuyu Chen, Dongyu Han, Jialiang Liu, Lin Lv, Jie Xiong, Keying Yuan, Xianpeng Wei, Siqi Sheng, Fukai Liu, Yuanqi Shi, Zengxiang Dong, Yue Li   +16 more
wiley   +1 more source

Engineering antisense oligonucleotides for targeted mRNA degradation through lysosomal trafficking. [PDF]

Chem Sci
Kashyap D, Milne TA, Booth MJ.
europepmc   +1 more source

Inorganic trimetaphosphatase as a histochemical marker for lysosomes in light and electron microscopy. [PDF]

, 1977
Stephen B. Doty, C E Smith, Arthur R. Hand, Constance Oliver   +3 more
openalex   +1 more source

Remodeling the Physicochemical and Pharmacokinetic Properties of PROTAC via Lipid Nanodisks for Cancer Therapy

Advanced Science, EarlyView.
To solve the challenge of PROTACs in clinical potential due to poor water solubility and membrane permeability, a nanodelivery system based on lipid nanodisks loaded with MZ1 prodrug (LND‐MZ1) to remodel the physicochemical and pharmacokinetic properties of PROTAC MZ1 is elaborately proposed.
Meichen Pan, Chunrong Yang, Zhongliang Fu, Yuchen Yang, Ying Zhuo, Hongwei Hou, Jinghong Li   +6 more
wiley   +1 more source

Biochemical Evidence for the Presence of Lysosomes in the Epidermis*

, 1966
Charles H. Dicken, Richard H. Decker
openalex   +1 more source

Studies on the structure-bound sedimentability of some rat liver lysosome hydrolases [PDF]

, 1971
Francesco M. Baccino, Giuseppe A. Rita, Maria Franca Zuretti   +2 more
openalex   +1 more source

Anti‐Inflammatory Mechanisms of Selenium Nanosheets in Ulcerative Colitis: Protein Corona, GP130 Interaction, and Transcriptomic Profile

Advanced Science, EarlyView.
SeNSs provide a biocompatible, anti‐inflammatory UC therapy. SeNSs form protein coronas enriched with AKT/PI3K/NF‐κB pathway proteins, suppress GP130 via hydrophobic interactions, and inhibit pro‐inflammatory cytokines. In DSS‐induced UC mice, SeNSs reduce inflammation, tissue damage, and disease activity by modulating cytokine, chemokine, and ...
Dingyi Shen, Li Gong, Wei Yang, Jiaqi Luo, Zhen Jin, Youzhi Tang   +5 more
wiley   +1 more source

β-Elemene induced ferroptosis via TFEB-mediated GPX4 degradation in EGFR wide-type non-small cell lung cancer

Journal of Advanced Research
Introduction: β-Elemene (β-ELE), derived from Curcuma wenyujin, has anticancer effect on non-small cell lung cancer (NSCLC). However, the potential target and detail mechanism were still not clear.
Li-Ping Zhao, Hao-Jie Wang, Die Hu, Jun-Hu Hu, Zheng-Rong Guan, Li-Hua Yu, Ya-Ping Jiang, Xiao-Qi Tang, Zhao-Huang Zhou, Tian Xie, Jian-Shu Lou   +10 more
doaj  

Deciphering tuberculosis: lysosome-centric insights into pathogenesis and therapies. [PDF]

Front Cell Infect Microbiol
Bao C, Zhang Y, Feng J, Hong X, Gao N, Feng G.   +5 more
europepmc   +1 more source

THE NEURONAL GOLGI APPARATUS AND LYSOSOMES IN NEONATAL RATS

, 1964
Norwin H. Becker, U. Sandbank
openalex   +1 more source