Results 201 to 210 of about 231,658 (339)

Loss of TMEM55B modulates lipid metabolism through dysregulated lipophagy and mitochondrial function. [PDF]

Cell Death Dis
Qin Y, Teker SS, La Cunza N, Tong Y, Theusch E, Yang NV, Venkatesan L, Su J, Wang X, Krauss RM, Lakkaraju A, Mattis AN, Medina MW.   +12 more
europepmc   +1 more source

Live Salmonella Modulate Expression of Rab Proteins to Persist in a Specialized Compartment and Escape Transport to Lysosomes [PDF]

, 2000
Shehla Hashim, Konark Mukherjee, Manoj Raje, Sandip K. Basu, Amitabha Mukhopadhyay   +4 more
openalex   +1 more source

Development of Endogenous Protein Probes for Characterizing Surface Proteins and Cellular Interactors of Extracellular Vesicles

Advanced Science, EarlyView.
The proximity labeling enzyme APEX2 is displayed on extracellular vesicle (EV) surfaces via genetic fusion with EV‐sorting scaffolds, enabling in situ biotinylation of native surface proteins, adsorbed corona components, and interacting cellular proteins.
Wenyi Zheng, Metoboroghene Mowoe, Wenqing Hou, Daniel W. Hagey, Koshi Imami, Samir EL Andaloussi   +5 more
wiley   +1 more source

Dysregulated TFEB-autophagy-lysosome pathway links acute COVID-19 immunopathology to Long COVID sequelae. [PDF]

Front Immunol
Gabig-Cimińska M.
europepmc   +1 more source

Promoting Autophagy Mitigates Stress‐Induced Remodeling in Patient iPSC‐CMs with the Phospholamban R9C Mutation

Advanced Science, EarlyView.
The Phospholamban (PLN) R9C mutation reduces SERCA2a binding, increasing calcium recycling and baseline contractility. However, the excess of free PLN promotes pentamer formation, limiting phosphorylation and blunting β‐adrenergic signaling. Under cardiac stress, enhanced functional demands overwhelm proteostasis in PLN R9C cells, leading to misfolded ...
Qi Yu, Yawei Shen, Robert J. Barndt, Karim Sallam, Ying Tang, Cameron E. Brown, Xiao Li, Stephen Y. Chan, Joseph C. Wu, Qing Liu, Haodi Wu   +10 more
wiley   +1 more source

pH-responsive bond as a linker for the release of chemical drugs from RNA–drug complexes in endosome or lysosome [PDF]

Piotr Rychahou, Sijin Guo, Yinan Zhang, Nicole Rychagov, Yekaterina Y. Zaytseva, Heidi L. Weiss, B. Mark Evers, Peixuan Guo   +7 more
openalex   +1 more source

Evaluation of the lysosome-associated membrane protein LAMP-2 as a marker for lysosomal storage disorders [PDF]

, 1998
Chi T. Hua, John J. Hopwood, Sven R. Carlsson, R. J. Harris, Peter J. Meikle   +4 more
openalex   +1 more source

Inhibition of SLC11A1‐Mediated Lysosomal Iron Accumulation in Microglia Promotes Repair Following White Matter Stroke

Advanced Science, EarlyView.
Genetic and pharmacological inhibition of SLC11A1 functioning as an H+/Fe2+ antiporter–mediated lysosomal iron accumulation in microglia promotes lysosomal lumen acidification, increases CTSD expression, enhances lysosomal myelin debris uptake and degradation, and promotes repair following white matter stroke. ABSTRACT White matter stroke (WMS) results
Lingling Qiu, Yajie Zhang, Yushi Tang, Hongli Hu, Ying Zhang, Junwen Xue, Hao Wang, Yecheng Wang, Chunfeng Liu, Jia Jia, Jian Cheng, Yongjun Cao   +11 more
wiley   +1 more source

Huntington's disease-associated ankyrin repeat palmitoyl transferases are rate-limiting factors in lysosome formation and fusion. [PDF]

PLoS Genet
Szenci G, Boda A, Nagy A, Károlyi D, Rubics A, Szőke Z, Falcsik G, Kovács T, Lőrincz P, Juhász G, Takáts S.   +10 more
europepmc   +1 more source

mTORC2 Activity Disrupts Lysosome Acidification in Systemic Lupus Erythematosus by Impairing Caspase-1 Cleavage of Rab39a [PDF]

, 2018
Andrew J. Monteith, Heather A. Vincent, SunAh Kang, Patrick Li, Tauris M. Claiborne, Zenon Rajfur, Ken Jacobson, Nathaniel J. Moorman, Barbara J. Vilen   +8 more
openalex   +1 more source