Results 301 to 310 of about 174,460 (337)

Targeted degradation of extracellular proteins: state of the art and diversity of degrader designs. [PDF]

J Hematol Oncol
Mamun MAA, Bakunts AG, Chernorudskiy AL.
europepmc   +1 more source

Correction: Hypoxia-triggered ERRα acetylation enhanced its oncogenic role and promoted progression of renal cell carcinoma by coordinating autophagosome-lysosome fusion. [PDF]

Cell Death Dis
Feng C, Kong D, Tong B, Liang Y, Xu F, Yang Y, Wu Y, Chi X, Wei P, Yang Y, Zhang G, Tian G, Xu Z.   +12 more
europepmc   +1 more source

Lysosomal Stress in Cardiovascular Diseases: Therapeutic Potential of Cardiovascular Drugs and Future Directions. [PDF]

Biomedicines
Otoda T, Aihara KI, Takayama T.
europepmc   +1 more source

Purifying and profiling lysosomes to expand understanding of lysosomal dysfunction-associated diseases. [PDF]

J Clin Invest
Shilatifard A, Ben-Sahra I.
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Senescent cell survival relies on upregulation of lysosomal quality control mechanisms

Curnock R, Carroll B.
europepmc   +1 more source

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Lysosomes and lysosomal cathepsins in cell death

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2012
Lysosomes are the key degradative compartments of the cell. Lysosomal cathepsins, which are enclosed in the lysosomes, help to maintain the homeostasis of the cell's metabolism by participating in the degradation of heterophagic and autophagic material. Following the targeted lysosomal membrane's destabilization, the cathepsins can be released into the
Urska Repnik, Veronika Stoka, Boris Turk, Vito Turk   +3 more
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Rethinking lysosomes and lysosomal disease

Neuroscience Letters, 2021
Lysosomal storage diseases were recognized and defined over a century ago as a class of disorders affecting mostly children and causing systemic disease often accompanied by major neurological consequences. Since their discovery, research focused on understanding their causes has been an important driver of our ever-expanding knowledge of cell biology ...
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Lysosomes, Lysosomal Enzymes, and Cancer

1992
Publisher Summary Lysosomes are membrane-enclosed cytoplasmic organelles, which posses an acidic interior that contains many hydrolytic enzymes. Their major function is in the the degradation of macromolecules, which may be cellular or foreign in origin.
Ian F. Tannock, Michael Boyer
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