Results 151 to 160 of about 26,398 (197)
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Lysyl oxidase in colorectal cancer
American Journal of Physiology-Gastrointestinal and Liver Physiology, 2013Colorectal cancer is the third most prevalent form of cancer worldwide and fourth-leading cause of cancer-related mortality, leading to ∼600,000 deaths annually, predominantly affecting the developed world. Lysyl oxidase is a secreted, extracellular matrix-modifying enzyme previously suggested to act as a tumor suppressor in colorectal cancer. However,
Cox, Thomas R, Erler, Janine T
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Lysyl Oxidase Isoforms in Gastric Cancer
Biomarkers in Medicine, 2016Gastric cancer (GC) is the fifth most frequent cancer in the world and shows the highest incidence in Latin America and Asia. An increasing amount of evidence demonstrates that lysyl oxidase isoforms, a group of extracellular matrix crosslinking enzymes, should be considered as potential biomarkers and therapeutic targets in GC.
Carolina, Añazco +7 more
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A microassay for lysyl oxidase activity
Analytical Biochemistry, 1976Abstract Pinnell and Martin's [(1968) Proc. Nat. Acad. Sci. USA61, 708–716] standard assay for lysyl oxidase is modified to determine activity in small samples. Data collected by both methods are comparable, and the microassay has the advantages of being economical and rapid.
Misiorowski, Ronald L. +2 more
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Active site chemistry of lysyl oxidase
Journal of Inorganic Biochemistry, 1987The bimolecular reduction of the Cu(II)-based enzyme lysyl oxidase with two inorganic reductants, tris bipyridylchromium(II) and (1,3,6,8,10,13,16,19)-octaazabicyclo (6,6,6)eicosanecobalt(II) has been examined at various ionic strength and [H+] conditions. The electrochemical properties of the enzyme have also been examined. The results show that Cu(II)
K, Govindaraju +3 more
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Respirology, 2015
Aim: The development of fibrosis in Idiopathic Pulmonary Fibrosis (IPF) is a key feature and challenge in the treatment of the disease. The mechanisms of collagen I (COL1) reorganisation in the development of fibrosis, which may alter the stiffness of the tissue, are not well understood.
Tjin, G. +4 more
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Aim: The development of fibrosis in Idiopathic Pulmonary Fibrosis (IPF) is a key feature and challenge in the treatment of the disease. The mechanisms of collagen I (COL1) reorganisation in the development of fibrosis, which may alter the stiffness of the tissue, are not well understood.
Tjin, G. +4 more
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An ultrafiltration assay for lysyl oxidase
Analytical Biochemistry, 1990A modification of the original microdistillation assay for lysyl oxidase is described in which Amicon C-10 microconcentrators are used to separate, by ultrafiltration, the 3H-labeled products released from a [4,5-3H]-lysine-labeled elastin substrate.
D R, Shackleton, D J, Hulmes
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Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1994
Lysyl oxidase initiates crosslink formation of the collagen and elastin extracellular matrix, thereby delimiting its expansive properties. Recently lysyl oxidase has been cloned from several species enabling the computation of the relative order of appearance of the various components of this enzyme system.
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Lysyl oxidase initiates crosslink formation of the collagen and elastin extracellular matrix, thereby delimiting its expansive properties. Recently lysyl oxidase has been cloned from several species enabling the computation of the relative order of appearance of the various components of this enzyme system.
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1989
The pH dependency of steady-state kinetic parameters and the results of chemical modification of lysyl oxidase by diethylpyrocarbonate has identified an enzyme residue with a pKa of 7.0 ± 0.1 and an enthalpy of ionization of 6.1 kcal mole-1, consistent with an active site histidine residue.
Herbert M. Kagan +4 more
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The pH dependency of steady-state kinetic parameters and the results of chemical modification of lysyl oxidase by diethylpyrocarbonate has identified an enzyme residue with a pKa of 7.0 ± 0.1 and an enthalpy of ionization of 6.1 kcal mole-1, consistent with an active site histidine residue.
Herbert M. Kagan +4 more
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Stability and purification of lysyl oxidase
Archives of Biochemistry and Biophysics, 1974Abstract Previous attempts to purify lysyl oxidase have been frustrated by the failure to recover activity during ion exchange or affinity chromatography. We have found that lysyl oxidase from chick cartilage shows marked stability in buffers containing urea and in these solutions can be recovered in high yield from DKAE-cellulose and collagen ...
A S, Narayanan, R C, Siegel, G R, Martin
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Immunological characterization of bovine lysyl oxidase
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1985Antibodies to homogeneously purified bovine aortic lysyl oxidase were prepared in chickens. The chicken anti-lysyl oxidase antiserum effectively inhibited bovine aortic lysyl oxidase activity. Non-immune antiserum from chickens, goats and humans was found to enhance bovine aortic lysyl oxidase activity, while non-immune rabbit serum inhibited enzyme ...
Burbelo, P. D. +2 more
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