Results 181 to 190 of about 155,219 (227)
Lysyl Oxidase Family Enzymes and Their Role in Tumor Progression
International Journal of Molecular Sciences, 2022 The five genes of the lysyl oxidase family encode enzymes that covalently cross-link components of the extracellular matrix, such as various types of collagen and elastin, and, thus, promote the stabilization of extracellular matrixes.
Shira Toledano +2 more
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A micromethod for the purification of lysyl oxidase
Analytical Biochemistry, 1982Abstract A simple, efficient, and rapid procedure for the purification of lysyl oxidase is described. This method utilizes an affinity scheme involving powdered elastin-hydroxyethylmethacrylate hydrogels and high-performance liquid chromatography and permits the study of enzyme from sources which contain limited amounts of enzyme, such as aortic ...
R, Ferrera +4 more
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Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1994
Lysyl oxidase initiates crosslink formation of the collagen and elastin extracellular matrix, thereby delimiting its expansive properties. Recently lysyl oxidase has been cloned from several species enabling the computation of the relative order of appearance of the various components of this enzyme system.
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Lysyl oxidase initiates crosslink formation of the collagen and elastin extracellular matrix, thereby delimiting its expansive properties. Recently lysyl oxidase has been cloned from several species enabling the computation of the relative order of appearance of the various components of this enzyme system.
openaire +2 more sources
Lysyl Oxidases: Functions and Disorders
Journal of Glaucoma, 2018Lysyl oxidases (LOX) are copper-dependent enzymes that oxidize lysyl and hydroxylysyl residues in collagen and elastin, as a first step in the stabilization of these extracellular matrix proteins through the formation of covalent cross-linkages, an essential process for connective tissue maturation.
Fernando, Rodriguez-Pascual +1 more
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Lysyl Oxidase and Lysyl Oxidase-Like Enzymes
2010Lysyl oxidase (LOX) and its four congeners, lysyl oxidase-like 1 (LOXL1), -2, -3, and -4, have received much investigative attention in recent years. LOX itself, is the prototypic form of these amine oxidase enzymes. LOX has long been considered to function exclusively as the enzyme that oxidizes peptidyl lysine in its collagen and elastin substrates ...
Herbert M. Kagan, Faina Ryvkin
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An ultrafiltration assay for lysyl oxidase
Analytical Biochemistry, 1990A modification of the original microdistillation assay for lysyl oxidase is described in which Amicon C-10 microconcentrators are used to separate, by ultrafiltration, the 3H-labeled products released from a [4,5-3H]-lysine-labeled elastin substrate.
D R, Shackleton, D J, Hulmes
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Stability and purification of lysyl oxidase
Archives of Biochemistry and Biophysics, 1974Abstract Previous attempts to purify lysyl oxidase have been frustrated by the failure to recover activity during ion exchange or affinity chromatography. We have found that lysyl oxidase from chick cartilage shows marked stability in buffers containing urea and in these solutions can be recovered in high yield from DKAE-cellulose and collagen ...
A S, Narayanan, R C, Siegel, G R, Martin
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Properties and Function of Lysyl Oxidase
American Journal of Respiratory Cell and Molecular Biology, 1991Abstract Lysyl oxidase catalyzes the oxidation of peptidyl lysine to α-aminoadipic-δ-semialdehyde, the precursor to the covalent crosslinkages that stabilize fibers of elastin and collagen. This enzyme contains both copper and a carbonyl cofactor consistent with an o-quinone.
H M, Kagan, P C, Trackman
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On the inhibition of lysyl oxidase by β-aminopropionitrile
Biochemical and Biophysical Research Communications, 1972Summary β-Aminopropionitrile binds to and inactivates lysyl oxidase, the enzyme carrying out the first step in the cross-linking of collagen and elastin.
A S, Narayanan, R C, Siegel, G R, Martin
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Respirology, 2015
Aim: The development of fibrosis in Idiopathic Pulmonary Fibrosis (IPF) is a key feature and challenge in the treatment of the disease. The mechanisms of collagen I (COL1) reorganisation in the development of fibrosis, which may alter the stiffness of the tissue, are not well understood.
Tjin, G. +4 more
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Aim: The development of fibrosis in Idiopathic Pulmonary Fibrosis (IPF) is a key feature and challenge in the treatment of the disease. The mechanisms of collagen I (COL1) reorganisation in the development of fibrosis, which may alter the stiffness of the tissue, are not well understood.
Tjin, G. +4 more
openaire +1 more source