Results 171 to 180 of about 152,902 (307)

Lytic Phase [PDF]

, 2020
openaire   +1 more source

Glomeruloid haemangioma in Erdheim–Chester disease: An atypical skin manifestation associated with elevated vascular endothelial growth factor‐A levels

British Journal of Haematology, EarlyView.
Glomeruloid haemangiomas and extensive angiomas occurred in a small subset of Erdheim–Chester disease patients, all showing markedly elevated vascular endothelial growth factor‐A (VEGF‐A) levels despite the absence of POEMS (polyneuropathy, organomegaly, M‐spike, and skin disease) syndrome.
Jerome Razanamahery, Matthias Papo, Francesco Pegoraro, Felix Blaison, Paul Legendre, Valentin Carado, Martin Caretti, Aubriot Lorton Marie Helene, Jean‐Francois Emile, Augusto Vaglio, Julien Haroche   +10 more
wiley   +1 more source

A System-Level Perspective on Epstein-Barr Virus Persistence: The Partial Lytic Reactivation. [PDF]

Int J Mol Sci
Michalak KP, Adamski W.
europepmc   +1 more source

MAFF Suppresses Necroptosis in Pancreatic Cancer via the GATA4‐MLKL Axis

Cancer Science, EarlyView.
MAFF promotes pancreatic cancer progression by acting as a transcriptional repressor of the GATA4‐MLKL axis, thereby inhibiting necroptotic cell death. This study identifies the MAFF‐GATA4‐MLKL pathway as a novel therapeutic target and a significant prognostic biomarker for pancreatic adenocarcinoma.
Xinwei Zhou, Zheng Zhao, Ning Sun, Daoyong Zhang   +3 more
wiley   +1 more source

Genomic and functional characterization of a novel halophilic bacteriophage targeting carbapenem-resistant Klebsiella pneumoniae. [PDF]

PLoS One
Abed S, Beig M, Soltani S, Pahlevani M, Speck P, Shafiei M, Shahraki AH, Ghorbani A.   +7 more
europepmc   +1 more source

Gasdermin‐Mediated Pyroptosis: Novel Strategies Against Colorectal Cancer

Cancer Science, EarlyView.
Pyroptosis is a double‐edged sword in colorectal cancer (CRC): chronic low‐grade pyroptosis promotes tumor progression, whereas acute induction of pyroptosis in cancer cells triggers antitumor immunity and enhances therapeutic response. Targeting gasdermin‐mediated pyroptosis represents a promising strategy for CRC treatment.
Kaibo Guo, Yuqian Feng, Jiamin Lu, Nuerbiye Abudurexiti, Xinlei Zhou, Mengfan Wei, Song Zheng   +6 more
wiley   +1 more source

Host microRNA-31-5p regulates KHDRBS3 expression and modulates viral gene expression during KSHV lytic reactivation. [PDF]

Cell Rep
Lee SM, Avalos CL, Miliotis C, Doh HM, Chan E, Kaye KM, Slack FJ.   +6 more
europepmc   +1 more source

Aptamer‐mediated outer membrane destabilization overcomes low permeability resistance in Pseudomonas aeruginosa

The FEBS Journal, EarlyView.
DNA aptamers, Apt 60 and Apt 173, target the BamA protein to compromise outer membrane integrity in Pseudomonas aeruginosa, making it susceptible to Azithromycin, an antibiotic that is otherwise poorly effective due to the low‐permeability membrane.
Rupany Selvam, Michelle Khai Khun Yap, Rafael Giacomazzi, Sérgio F. Sousa, Hock Siew Tan   +4 more
wiley   +1 more source

The building blocks of phage therapy: from lytic phage identification to preclinical validation against antimicrobial-resistant critical priority bacteria. [PDF]

Microbiol Spectr
Vale FF.
europepmc   +1 more source

Targeted, receptor‐mediated delivery of a masked d‐amino acid cell‐penetrating peptide for cell‐specific phototoxicity

The FEBS Journal, EarlyView.
A targeted phototoxic peptide selectively accumulates in cells expressing chemokine‐like receptor 1 (CMKLR1). Phototoxicity of the native peptide is low, but cleavage by lysosomal protease cathepsin B releases a 6‐tetramethylrhodamine (TMR) labeled nona‐ᴅ‐arginine which mediates lysosomal rupture and cell death upon irradiation.
Moritz List, Eva‐Maria Jülke, Annette G. Beck‐Sickinger   +2 more
wiley   +1 more source