Results 101 to 110 of about 1,125,732 (289)

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Estimativa de custo do método Famacha utilizado no controle de verminoses gastrintestinais em pequenos ruminantes. [PDF]

, 2019
Os helmintos gastrintestinais são responsáveis por enfermidades em ovinos e caprinos. Dentre eles destaca-se o Haemonchus contortus, responsável por um quadro clínico de anemia, que pode ser detectada pelo método FAMACHA.
MARTINS, E. C., MEDEIROS, H. R. de, NAVARRO, A. M. do C., NEVES, M. R. M. das, VIEIRA, L. da S., ZAROS, L. G.   +5 more
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Tubule‐Derived IFN‐α Promotes GSDMD‐Mediated Macrophage Pyroptosis to Drive Renal Inflammation and Fibrosis Through JAK2/STAT2 Activation

Advanced Science, EarlyView.
Mao and colleagues uncover a STAT2/IRF9‐dependent signaling axis through which tubular epithelial cell (TEC)‐derived IFN‐α induces gasdermin D (GSDMD)‐mediated pyroptosis in macrophages. This TEC‐macrophage feedback loop amplifies renal inflammation and fibrosis, providing mechanistic insight into the progression of chronic kidney disease and revealing
Yiping Xu, Yating Wang, Siming Jiang, Yi Li, Guanglan Li, Yuchu Liu, Siyuan Li, Yiming Zhou, Qinghua Liu, Yi Zhou, Wei Chen, Hongyu Li, Haiping Mao   +12 more
wiley   +1 more source

O cineasta e o pintor [PDF]

, 2009
“Para saber o que se passa na cabeça de um pintor, basta seguir a sua mão”. Este é o propósito revelado pelo realizador Henri-Georges Clouzot no preâmbulo do filme "Le Mystère Picasso" que, como André Bazin sublinhou desde logo, “não explica coisa
Lisboa, Nuno
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The Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis

Advanced Science, EarlyView.
Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao, Juan Ignacio Jiménez‐Loygorri, Yunguang Qiu, You Jung Kang, Khanh Van Do, Annabel E. Smith, Junjie Huang, Jun‐ping Pan, Lipeng Mao, Ang Li, Hangge Yang, Yahyah Aman, Maria Jose Donate Lagartos, Sofie Hindkjær Lautrup, Anbin Chen, Kristina Xiao Liang, Hailong Zhang, Juan Yi, Xurui Jin, Tin Cho Cheung, Olympia Apokotou, Florentia Papastefanaki, Rebecca Matsas, William A. McEwan, Feixiong Cheng, Hansang Cho, Guobing Chen, Huanxing Su, Konstantinos Palikaras, Oscar Junhong Luo, Qian Hua Zhao, Ding Ding, Cornelia van Duijn, Nektarios Tavernarakis, Patricia Boya, Tewin Tencomnao, Evandro F. Fang   +36 more
wiley   +1 more source

A mão suja

Comunicação & Educação, 2003
Poema
Carlos Drummond de Andrade
doaj  

Development and applications of micro-arc oxidation technology

Cailiao gongcheng, 2019
The development status of micro-arc oxidation (MAO) technology at home and abroad was reviewed. The principle and process characteristics of MAO technology were primarily introduced.
SONG Ren-guo
doaj   +1 more source

Políticas criminais dos últimos 25 anos e o desequilíbrio do sistema de justiça em Portugal [PDF]

, 2005
“Crise da justiça” é uma expressão muito comum hoje em dia. É tão vulgar como a própria palavra de “justiça”. Andamos de mão em mão. A situação calamitosa do funcionamento do sistema de justiça, que se encontra repetidamente na agenda política de governo
Mendes, Silvia M.
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Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

Sistemas autoirrigados de produção agrícola. [PDF]

, 2017
Com a crescente urbanização e a alta demanda de mão de obra para a produção de diversas culturas agrícolas ou ornamentais, há uma busca do mercado por alternativas tecnológicas que contribuam para o aumento da produtividade sem afetar a qualidade do ...
GUIMARAES, D. P., LANDAU, E. C.
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