Results 151 to 160 of about 146,884 (299)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Programa seis sigma em pequenas e médias empresas: revisão e recomendações
, 2010 Carlos Henrique Mora Júnior +1 more
openalex +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Éducation et médias, l’apport de Louis Porcher
, 2016 International audienceAvant même les débuts de la presse de masse, des penseurs s’interrogent sur l’impact des journaux sur les jeunes lecteurs. Mais c’est au XXe siècle que l’éducation aux médias est pensée et structurée progressivement dans le domaine ...
Corroy, Laurence, Laurence, Corroy
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Analyse du traitement de l'information dans la presse écrite traditionnelle et dans les médias socionumériques : étude de cas sur le mois de la sensibilisation à la maladie d'Alzheimer [PDF]
, 2013 Esteban Antonio Bongiovanni
openalex
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Éducation aux médias, citoyenneté et créativité, les enjeux de l’éducation aux médias au XXIe siècle
, 2016 National audienceL'éducation aux medias a un rôle essentiel à jouer, pragmatique : il s'agit tout autant de dénaturaliser les médias, au sens où l'entend Len Masterman, par l'analyse et la déconstruction des discours qui sont proposés, que de développer
Corroy, Laurence, Laurence, Corroy
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Thermal Safety of Forced-Air Warming During Balloon Occlusion in Isolated Perfusion Chemotherapy: A Prospective Feasibility Study Using Multisite Temperature Monitoring. [PDF]
Cancers (Basel)Aust H, Kranke P, Torossian A, Aigner K.
europepmc +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
, 2013 Participant au développement corporel, véhiculant des messages, s'imposant comme un enjeu financier d'envergure, séduisant les médias de masse, le sport, par ses tutelles, est assimilé institutionnellement à la jeunesse.
Corroy, Laurence, Laurence, Corroy
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