Results 31 to 40 of about 15,930 (146)
Je considère L’Éducation sentimentale comme un des premiers romans de la ville moderne, et je cherche des moments textuels dans lesquels la Ville structure l’espace du roman, la conduite du récit et la poétique de l’œuvre.
Jeanne Bem
doaj +1 more source
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Penser l’entrelacs des religions et des médias
Les religions et les médias parlent les unes des autres, s’utilisent mutuellement. Cet article introductif entend montrer comment les deux se trouvent mis en tension, pose quelques réflexions d’ordre épistémologique et sur le champ de recherche, en voie ...
David Douyère, Frédéric Antoine
doaj +1 more source
Depuis quelques années, on remarque plus d’études consacrées aux arts autochtones au Québec. Parmi celles-ci, on en retrouve peu sur les arts médiatiques et numériques ou alors, elles sont publiées surtout en anglais.
Caroline Nepton Hotte
doaj +1 more source
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Us ou abus… pour le sociologue, la réalité sociale est grise. Entretien avec Rémy Rieffel
Rémy Rieffel est professeur en Sciences de l’information et de la communication à l’université Paris 2 Panthéon-Assas et sociologue des médias. Il est directeur du Centre d’analyse et de recherche interdisciplinaire sur les médias (Carism) et enseignant ...
Vassili Rivron, Cécile Dolbeau-Bandin
doaj +1 more source

