Results 61 to 70 of about 33,519 (162)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, Volume 20, Issue 5, Page 1161-1184, May 2026.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Métastase surrénalienne d’un carcinome hépatocellulaire (CHC) : à propos d’un cas [PDF]

, 2008
Le carcinome hépatocellulaire (CHC) est un des cancers les plus fréquents dans le monde. Plusieurs facteurs favorisent sa survenue, parmi lesquels la cirrhose est considérée, depuis longtemps, comme un des facteurs étiologiques majeurs du CHC. Le CHC est
BELLASRI, salah
core  

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, Volume 20, Issue 5, Page 1364-1378, May 2026.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, Volume 20, Issue 5, Page 1115-1139, May 2026.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Metástase Vaginal como Manifestação Inicial de Carcinoma de Células Renais

Revista Brasileira de Cancerologia, 2008
A ocorrência de metástases de carcinoma de células renais para a vagina é rara. Ocorre principalmente em mulheres na pós-menopausa e o principal fator prognóstico é se essa metástase apresenta-se ou não isolada. Poucos casos foram relatados na literatura
Marília Buenos Aires Cabral Tavares, Amanda Correia da Paz, Adriano Leite Camilo da Silva, Rodrigo Beserra Sousa, João Rubens Agostinho Rolim, Carolina Buenos Aires Cabral Tavares, Sabas Carlos Vieira   +6 more
doaj   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, Volume 16, Issue 5, Page 979-999, May 2026.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Métastase atypique du cuir chevelu et surrénalienne d’un carcinome urothelial de la vessie [PDF]

, 2016
Les métastases du cuir chevelu et surrénaliennes d'un carcinome urothélial de la vessie sont rares, peu de cas ont été rapportés dans la littérature, et la chimiothérapie est le traitement de choix.
Kebdani, Tayeb, James, Laurianne, Rahali, Leila, Kettani, Fouad, Benjaafar, Noureddine, Dossou, Serpos, Irigo, Joelle, Ogandaga, Etienne, Bazine, Amine, Afif, Mohammed   +9 more
core   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, Volume 16, Issue 5, Page 1000-1019, May 2026.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Métastase au XIXe siècle : l'expérience de l'"Alessandro nell'Indie" de Giovanni Pacini (1824) [PDF]

, 2009
International audienceAnalyse de la dernière adaptation musicale d'un livret de Métastase ayant connu un nombre très élévé de versions ; approche historique, suivie de la mise en regard la structure et de la versification de cette mouture et de celle de ...
Faverzani, Camillo
core   +1 more source

LAT1/SLC7A5‐mediated amino acid uptake is regulated by redox signals triggered by formyl‐peptide receptor 2

The FEBS Journal, Volume 293, Issue 9, Page 2637-2655, May 2026.
FPR2 activation mediates NOX‐dependent LAT1 expression and, in turn, promotes mTORC1 signaling. Upon stimulation with WKYMVm, the FPR2‐NOX2‐ROS axis upregulates LAT1 via increased c‐Myc phosphorylation and decreased miR‐126. Additionally, it promotes CD98 translocation to the plasma membrane.
Myrhiam Cassese, Chiara Brignola, Stefano Marrone, Gabriella Esposito, Rosario Ammendola, Fabio Cattaneo   +5 more
wiley   +1 more source