Results 21 to 30 of about 18,955 (175)

Métastases cutanées d’un carcinome vulvaire [PDF]

, 2016
Les métastases cutanées (MC) sont rares. Elles représentent généralement un stade évolutif avancé de la maladie cancéreuse. BF, âgée de 64 ans, a été suivie pour un carcinome épidermoïde vulvaire traité par vulvectomie totale, curage ganglionnaire ...
Rachadi, Hanane, Ramli, Inssaf
core   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Copine‐4 Paraneoplastic Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We characterize copine‐4 (CPNE4)‐IgG and report clinical associations. Among 844 samples with unclassified neural IgGs identified by mouse‐brain indirect immunofluorescence assay over 2 years, 5 samples (serum, 3; CSF, 2) from 3 patients produced a distinctive cerebrum‐restricted synaptic pattern.
Mimi S. Fang, Amy Ml Quek, Clement Yong, Amir Adeli, Gabrielle N. Conway, Connie E. Lesnick, Diana Anissian, Divyanshu Dubey, John R. Mills, Sean J. Pittock, Anastasia Zekeridou, Michael Gilligan, Andrew McKeon   +12 more
wiley   +1 more source

SemanticST: A Scalable Multi‐Contextual Graph Learning Framework for Uncovering Spatial Niches and Robust Multi‐Sample Integration in Spatial Transcriptomics

Advanced Science, EarlyView.
Technical limitations often let dominant signals overshadow rare cell types and fine‐grained heterogeneity in spatial transcriptomics. SemanticST, a graph neural network using multi‐semantic graph fusion and a novel min‐cut loss, recovers these subtle patterns.
Roxana Zahedi, Ahmadreza Argha, Nona Farbehi, Ivan Bakhshayeshi, Thantrira Porntaveetus, Youqiong Ye, Nigel H. Lovell, Hamid Alinejad‐Rokny   +7 more
wiley   +1 more source

Patient‐Derived Glioblastoma Organoids for AI‐Guided Prediction of Therapeutic Response

Advanced Science, EarlyView.
Patient‐derived glioblastoma organoids provide clinically relevant models that preserve tumor heterogeneity and enable integrated AI‐driven analysis of imaging, molecular, and treatment‐response data. Their convergence with advanced analytics supports predictive, personalized therapeutic strategies and may accelerate translation from patient‐specific ...
Sandbhor Puja, Arun Bhavyadharshini, John Geofrey, Mudliyar Siddharth, Ghanekar Shubham, Moyiadi Aliasgar, Shetty Prakash, Singh Vikas, Sadwani Nidhisha, Garg Akshohini, Sahay Ayushi, Chatterjee Abhishek, Epari Sridhar, Gupta Tejpal, Dasgupta Archya, Goda Jayant   +15 more
wiley   +1 more source

Prevalence and Clinicopathological Profile of Bone Metastases in Patients with Solid Tumours in an Oncology Department of Abidjan: A Five-Year Retrospective Study

Health Research in Africa
Background. Bone metastases are a frequent manifestation of advanced cancer, causing major skeletal-related events (SREs) and impairing quality of life. Local data from Côte d'Ivoire remain scarce.
Mébiala NMP, Odo BA, Kouassi KKY, Touré PGLK, Sességnon FA, Nobou AMBY, Madiou MKA, Grahoury JB, Touré M   +8 more
doaj   +1 more source

Évaluation de la radiothérapie stéréotaxique hypofractionnée des métastases cérébrales sur le centre Henri Becquerel : Étude STECER

, 2021
Étudier le contrôle local, le contrôle cérébral, la survie globale et la tolérance chez les patients présentant une ou plusieurs métastases cérébrales ayant reçu une radiothérapie stéréotaxique hypofractionnée (RSHF) ; évaluation des facteurs associés ...
Amar, Sandrine
core  

18F‐FGln PET/CT Imaging of Glutamine Uptake Has Potential for Predicting Immunotherapy Response in Hepatocellular Carcinoma

Advanced Science, EarlyView.
18F‐FGln PET/CT imaging serves as a marker of Gln uptake in hepatocellular carcinoma. Tumors with high Gln uptake drive Treg‐mediated immunosuppression and immune evasion during antitumor immunotherapy. Conversely, tumors with low Gln uptake maintain sufficient Gln in the TME, suppressing Tregs and enabling cytotoxic T cells to inhibit tumor growth ...
Yi Liu, Jindian Li, Xiaoyu Pan, Xiaoping Xu, Xuan Huang, Simin He, Jianping Zhang, Fei Liu, Shaoli Song   +8 more
wiley   +1 more source

Complexity of neuro-oncological in-hospital consultations: a multicentre study

Neurología (English Edition)
Introduction: Oncological patients may require evaluation by a neurologist when they are admitted to hospital. The aim of our study was to determine the frequency and characteristics of hospital interconsultations (IC) received by the neurology ...
C. Jauregui Larrañaga, M. Villagrán-García, J. Cabello Murgui, M.I. Barceló Artigues, E. Bargay Pizarro, M.C. Gil Alzueta, I. Esparragosa Vázquez, L. Bataller Alberola, R. Velasco Fargas, M.E. Erro Aguirre   +9 more
doaj   +1 more source

Translational Macrophage Mechano‐Immunotherapy for Next‐Generation Implantable Biomaterials

Advanced NanoBiomed Research, EarlyView.
This review explores how macrophage mechanosensing drives inflammation, fibrosis and foreign body responses to implanted biomaterials. It examines emerging pharmacological strategies to modulate mechanotransduction, alongside biomaterial platforms for localised drug delivery, clinical translation, regulatory considerations and standardised testing ...
Xueying Xu, Ian L. Chin, Richard P. Tan
wiley   +1 more source