Results 101 to 110 of about 7,407 (233)

Lactate‐Driven Restriction of Mitochondrial Permeability Transition Promotes Resistance to Chemo‐Immunotherapy by Suppressing Tumor PANoptosis

Advanced Science, EarlyView.
Tumor‐derived lactate establishes a metabolic lock that drives chemo‐immunotherapy resistance by suppressing PANoptosis. Mechanistically, KAT8 lactylates the mitochondrial translocator ANT2, which recruits PGAM5 to dephosphorylate CypD. This cascade restricts mitochondrial permeability transition pore opening, preventing pro‐inflammatory mtDNA leakage.
Sen Zhong, Wenlong Chen, Fanglong Liu, Shengyi Zhou, Bolin Yu, Yuying Wang, Xiqian Zhou, Xuehui Wang, Diya Liu, Zhuoyu Zhang, Xinran Wang, Mounia Lalouly, Yiwen Li, Zhefei Du, Tao Yan, Zhihui Xiao, Zhou Zhou, Huanhuan Zhu, Fengyuan Qian, Bowen Zheng, Lin Fang   +20 more
wiley   +1 more source

La mímesis en el teatro clásico [PDF]

, 2013
In this work I pretend to present partially the general thesis of my work: Theater is Essentially Mimesis. Also, I would like to associate mimesis with an emotional, sensitive component to demonstrate that this is precisely the expressive phenomenal ...
Zuluaga Gómez, Rubén Darío
core   +1 more source

MAM‐Localized MANF Counteracts Microinflammatory Stress to Attenuate Mitochondrial Dysfunction and Cataractogenesis in High Myopia

Advanced Science, EarlyView.
Chronic microinflammation in high myopia suppresses MANF in lens epithelial cells. MANF normally resides within MAMs and promotes ubiquitin‐mediated degradation of the ER Ca2+ pump SERCA2. MANF loss causes pathological SERCA2 accumulation, MAM hyperassembly, and disrupted ER‐to‐mitochondria Ca2+ transfer, leading to mitochondrial failure, oxidative ...
Xin Liu, Hao Li, Ching Kang, Dongling Guo, Shuyu Liu, Jiaqi Meng, Zhiqian Huang, Yu Du, Xiangjia Zhu   +8 more
wiley   +1 more source

De la calle al teatro y del teatro al texto

Verba Hispanica
El artículo explora las formas de teatralización de la violencia en la literatura dramática hispanoamericana. Una de las consecuencias del «giro performativo» en las artes escénicas (Fischer-Lichte) es la prevalencia de lo contingente del hecho teatral ...
Daniel Vázquez Touriño
doaj   +1 more source

An epidemiological model for mosquito host selection and temperature-dependent transmission of West Nile virus. [PDF]

Sci Rep, 2022
Fasano A, Riccetti N, Angelou A, Gomez-Ramirez J, Ferraccioli F, Kioutsioukis I, Stilianakis NI.   +6 more
europepmc   +1 more source

Pathological Copper Overload Reprograms SOD1 Activation via COMMD1 to Promote Senescence and Fibrosis

Advanced Science, EarlyView.
This study uncovers a previously unrecognized copper‐COMMD1‐SOD1 regulatory axis, revealing that pathological copper overload paradoxically suppresses SOD1 activity by promoting COMMD1‐dependent disruption of SOD1 homodimerization. These findings redefine the regulatory role of copper in SOD1 biology and provide novel mechanistic insight into the ...
Yuqing Liu, Jing Liu, Wenqian Zhou, Yangyang Niu, Yan Zheng, Yiguo Liu, Yingying Zhang, Chen Yu   +7 more
wiley   +1 more source

Análisis del concepto de mímesis en la antigua Grecia y en los diálogos III y X de La República de Platón

Revista Filosofía UIS
En este artículo se analizará el concepto de mímesis, término de gran relevancia en la antigua Grecia, especialmente en el arte y que fue objeto de reflexión por parte de destacados filósofos griegos, uno de ellos fue Platón, quien ofreció una ...
Diego Armando Jaimes Ramirez
doaj   +1 more source

An Immediate‐Response Detection System for γ‐Hydroxybutyrate to Enhance Personal Safety in Social Environments

Advanced Science, EarlyView.
A graphene‐based electrical biosensor enables rapid and highly sensitive detection of GHB at 100 fm in both standard solutions and artificial urine, providing reliable point‐of‐need screening for drug‐facilitated sexual assault. The platform demonstrates strong selectivity, fast response, and a wide dynamic range, supporting accurate detection in ...
Jai Eun An, Jisung Kwak, Kyung Ho Kim, Chaeeun Kim, Sung Eun Seo, Nathaniel S. Hwang, Yong‐Sang Ryu, Hyun Seok Song, Oh Seok Kwon   +8 more
wiley   +1 more source

Los peregrinos urbanos en Qoyllurit’i y el juego mimético de miniaturas

Anthropologica, 2010
Este artículo trata de los peregrinos de la ciudad de Cusco que participan en el juego de miniaturas en el santuario de Qoyllurit’i. Partiendo de una descripción del contexto socioeconómico urbano y de la ontología andina, este trabajo se propone ...
Astrid B. Stensrud
doaj  

Oral Prebiotic Polysaccharide Hydrogels Sustaining Colon Antibody Release Alleviate Inflammatory Bowel Disease

Advanced Science, EarlyView.
An orally administered prebiotic polysaccharide hydrogel (predaGel) based on inulin and alginate‐dopamine is stable in the stomach, adheres to the intestine, and degrades slowly in the colon. It enables site‐specific delivery of anti‐TNF‐α and anti‐IL‐12/23 antibodies, scavenges reactive oxygen species, and remodels gut microbiota, offering effective ...
Xinyi Dong, Huan He, Li Cao, Fenghua Meng, Zhiyuan Zhong   +4 more
wiley   +1 more source