Advanced NanoBiomed Research, EarlyView.This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari +5 more
wiley +1 more source
The Far Side of Carboranes: Anticancer Active Monocations and Ambiently Stable Dications
Angewandte Chemie, EarlyView.This work describes the synthesis of bench‐stable dicationic carboranes. Their enhanced electrophilicity is documented by opening the clusters with weak nucleophiles or dihydrogen. The surprising stability of positively charged carboranes in water enabled a study of their in vitro antiproliferative activity, which surpassed the effects of doxorubicin ...
Vlastimil Němec +10 more
wiley +2 more sources
Literal Pattern Analysis of Texts Written with the Multiple Form of Characters: A Comparative Study of the Human and Machine Styles. [PDF]
Entropy (Basel)Hayata K.
europepmc +1 more source
Advanced NanoBiomed Research, EarlyView.Glioblastoma mortality is driven by cell invasion and therapeutic resistance. We report a cancer engineering approach to evaluate the behavior of heterogeneous cohorts of temozolomide resistant and responsive GBM cells. We show the effect of physiologically‐relevant metronomic dosing on ensemble drug response and invasion.
Victoria A. Kriuchkovskaia +5 more
wiley +1 more source
Incidence of gastrointestinal helminth parasites of free-ranging domestic dogs from the web valley, Bale mountains National park, Ethiopia. [PDF]
BMC Vet ResMengistu GA +3 more
europepmc +1 more source
Problemática del género (cine y teatro) entre el "Molière" de Ariane Mnouchkine y el de Sabina Berman [PDF]
, 2008 Cornellà, Elena
core
Direct Selection of Functional De Novo Macrocycles for Activation of On‐Cellulo Insulin Receptor
Angewandte Chemie, EarlyView.A live‐cell screening platform, RaPID‐ExCells, integrates mRNA display‐derived macrocyclic peptide libraries with functional selection against native cell‐surface receptors. Application to the insulin receptor enabled de novo discovery of a macrocyclic agonist that activates endogenous signaling despite weak in vitro binding, highlighting the power of ...
Yun‐Hsuan Kuo +3 more
wiley +1 more source
ChatGPT: The Good, The Bad, and Everything in Between. [PDF]
Indian Dermatol Online JManohar N, Prasad SS, Pise G.
europepmc +1 more source
Structural Mechanism of an Efficacy Photoswitch Targeting the β2‐adrenergic Receptor
Angewandte Chemie International Edition, EarlyView.Time‐resolved structures from x‐ray free‐electron laser measurements combined with cellular assays demonstrate how the photoswitchable β‐blocker photoazolol‐1 acts as an efficacy switch of β2‐adrenergic receptor function. Light‐induced ligand repositioning shifts activity from inverse agonism toward neutral antagonism by altering local helical ...
Robin Stipp +29 more
wiley +1 more source
Therapeutic communication laboratory: integrating mixed methods with digital tools and reflective professional practice. [PDF]
Front PsycholMolinero F +4 more
europepmc +1 more source