Results 151 to 160 of about 111,163 (223)

Vaspin identified as a DNA‐binding serpin with functional consequences for protease inhibition

The FEBS Journal, EarlyView.
Vaspin is a serpin that is expressed in skin, adipose tissue, and liver. It binds to single‐ and double‐stranded DNA with high affinity. This binding is unaffected by mutation of the known heparin‐binding site, accelerates the inhibition of the inflammatory protease KLK7, and may contribute to vaspin's nuclear localization.
Kevin Möhlis, Abibe Useini, Heike Betat, Sonja Bonin, Helen Broghammer, Rima Nuwayhid, Stefan Langer, Mario Mörl, Norbert Sträter, John T. Heiker   +9 more
wiley   +1 more source

Radiotherapy and survival in elderly grade 4 glioma patients: The prognostic value of onco-functional outcome. [PDF]

Clin Transl Radiat Oncol
Hou HX, Leiss SM, Schmottermeyer D, Diehl C, Wiestler B, Peeken J, Borm K, Negwer C, Wagner A, Yakushev I, Delbridge C, Mitsdoerffer M, Schmidt-Graf F, Meyer B, Combs S, Bernhardt D.   +15 more
europepmc   +1 more source

Ligand‐specific tuning of CLEC10A signalling strength and dendritic cell responses through engagement of different GalNAc‐containing glycan structures

The FEBS Journal, EarlyView.
The authors investigated the effects of various glycan ligands for CLEC10A, a lectin receptor expressed on dendritic cells (DCs). Monocyte‐derived DCs were stimulated with glycan‐conjugated dendrimers in combination with the TLR1/2 ligand Pam3CysK4, and responses were investigated at the mRNA and protein level.
Nadia L. van der Meijs, Remi Hatinguais, Mike de Kok, R. J. Eveline Li, Tesfay M. Godefa, Victor L. J. L. Thijssen, Yvette van Kooyk, Sandra J. van Vliet   +7 more
wiley   +1 more source

SARS‐CoV‐2 nucleocapsid protein variants have differential RNA chaperone activity

The FEBS Journal, EarlyView.
The SARS‐CoV‐2 nucleocapsid (N) protein facilitates RNA annealing through its RBD–IDR2–CTD region, identifying it as a functional RNA chaperone. The Omicron BA.5 variant shows reduced chaperone activity compared to the Wuhan wild‐type protein. Although phosphorylation has no effect on wild‐type N, phosphomimetic modification of BA.5 N restores its RNA ...
Sabrina Babl, Julia M. Seidel, Fabian Kugler, Elisabeth Silberhorn, Anna Ludwig, Jonas Abel, Sophia Winklbauer, Niklas Schaub, Silvia Materna‐Reichelt, Kamran Honarnejad, Nataša Stojanović Gužvić, Gernot Längst   +11 more
wiley   +1 more source

Corrigendum to "Effects of modified release hydrocortisone on restoration of early morning cortisol, quality of life, and fatigue in adrenal insufficiency (The CHAMPAIN study): a randomised, double-blind, double-dummy, cross-over study comparing Chronocort and Plenadren"[eClinical Medicine 91(2026); 103714]. [PDF]

EClinicalMedicine
Prete A, Theiler-Schwetz V, Arlt W, Hazeldine J, Chifu IO, Harbeck B, Napier C, Newell-Price JDC, Rees DA, Reisch N, Stalla GK, Coope H, Maltby K, Porter J, Quirke J, Ross RJ.   +15 more
europepmc   +1 more source

Comparative analysis of metabolic and functional cardiac alterations in diet‐ and genetically induced mouse models of cardiac dysfunction

The FEBS Journal, EarlyView.
Dietary and genetic stress trigger different routes to heart failure. In mice, a carbohydrate‐free high‐fat diet caused mitochondrial dysfunction and impaired energy production with preserved pumping function, while genetic obesity led to heart enlargement, fibrosis, and reduced function.
Christiane Ott, Patricia Baumgarten, Thorsten Henning, Daniela Weber, Iwona Wallach, Jana Grune, Ulrich Kintscher, Hermann‐Georg Holzhütter, Tilman Grune, Nikolaus Berndt   +9 more
wiley   +1 more source

Identification of biomedical entities from multiple repositories using a specialized metadata schema and search-augmented large language models. [PDF]

BMC Res Notes
Kaier K, Engel F, Benadi G, Giuliani C, Watter M, Kalantari A, Schuller K, Franzke CW, Sperandio M, Binder H.   +9 more
europepmc   +1 more source

What Drives Sustainable Institutional Engagement and Voting Behavior?

Financial Review, EarlyView.
ABSTRACT We examine what drives institutional engagement and voting on environmental, social, and governance (ESG)‐related shareholder proposals, using data from Principles for Responsible Investment (PRI) and Morningstar. We find that personal engagement often substitutes for voting, especially among large fund families and those using meetings or ...
Martin Nerlinger, Martin Rohleder, Marco Wilkens, Jonas Zink   +3 more
wiley   +1 more source

Efficacy of Intravenous Immunoglobulin in Eliminating De Novo Donor-Specific Antibodies After Lung Transplantation: Importance of Early Intervention. [PDF]

Transpl Int
Vorstandlechner M, Degenfelder P, Yavuz G, Glueck OM, Kovács JR, Walter J, Dick A, Michel S, Schneider CP, Zoller M, Barton J, Kauke T.   +11 more
europepmc   +1 more source