Results 41 to 50 of about 111,163 (223)

Isolation Defines Identity: Functional Consequences of Extracellular Vesicle Purification Strategies

open access: yesAdvanced Healthcare Materials, EarlyView.
Four extracellular vesicle purification strategies are compared using ovarian‐cancer ascites and ES‐2 cell supernatants. A novel workflow links purification to function by combining particle‐normalized proteomics with matched cell‐free and cell‐based assays.
Christian Preußer   +10 more
wiley   +1 more source

München, Roma, ChristianiaKomposisjon og kunsthistorie i altertavlen Adolph Tidemand aldri malte

open access: yesKunst og Kultur, 2019
Denne artikkelen undersøker Adolph Tidemands studiereise til München og Roma i 1841–42, og hvordan han gjorde bruk av kunsthistoriske forlegg i oppbyggingen av egne komposisjoner.
Eilif Salemonsen
doaj   +1 more source

Die Entdeckung der Entdecker [PDF]

open access: yesRechtsgeschichte - Legal History, 2002
Rezensiertes Werk:Thomas Hoeren (Hg.), Zivilrechtliche Entdecker, München: Beck 2001, V, 442 S., ISBN 3-406-47962 ...
Natascha Doll
doaj   +1 more source

A Soft Robotic Fish With a Dielectric Elastomer Actuator Body and Negative Stiffness Spine

open access: yesAdvanced Robotics Research, EarlyView.
This work introduces a bio‐mimetic soft robotic fish driven by fiber‐reinforced dielectric elastomer actuators integrated as its body. By prestretching this active skin against a flexible spine, a negative stiffness system is created, enabling large‐amplitude bending.
Markus Koenigsdorff   +4 more
wiley   +1 more source

Predicting Macrophage Spatial Localization from Single‐Cell Transcriptomes to Uncover Disease Mechanisms

open access: yesAdvanced Science, EarlyView.
This study presents a machine‐learning framework entitled MERLIN that infers the microanatomical localization of macrophages from single‐cell transcriptomic data in structured organs such as the kidney and brain. Applying this method to existing datasets from models of acute kidney injury and diabetic nephropathy uncovered spatially resolved insights ...
Junping Yin   +18 more
wiley   +1 more source

Covalent Organic Framework–Carbon Nanotube Core–Shell Nanohybrids for Enhanced Catalytic Site Utilization of Molecular Catalysts in CO2 Electroreduction

open access: yesAngewandte Chemie, EarlyView.
Covalent organic framework–carbon nanotube (COF–CNT) core–shell nanohybrids are developed as an efficient platform to enhance the site utilization of molecular catalysts for electrochemical CO2 reduction. The well‐defined nanostructure promotes catalytic site accessibility, achieving CO turnover frequencies among the highest reported to date.
Liang Yao   +8 more
wiley   +2 more sources

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

open access: yesAdvanced Science, EarlyView.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun   +7 more
wiley   +1 more source

Small‐Molecule Activation of mRNA Translation by Click‐to‐Release Reaction in Cells

open access: yesAngewandte Chemie, EarlyView.
A new method to control mRNA activity using bioorthogonal click‐to‐release reactions is presented. The 5′ cap is modified with a trans‐cyclooctene (TCO) that quickly reacts with hydroxyaryl‐tetrazines and efficiently releases the native cap 0. TCO‐capped mRNAs are initially translationally inactive but can be activated with non‐toxic, cell‐permeable ...
Tess Vosman   +5 more
wiley   +2 more sources

Single‐Cell Metabolic Imaging and Digital Scoring of Fat Tissue Remodeling by Label‐Free Metabolic Microscopy

open access: yesAdvanced Science, EarlyView.
Mid‐infrared optoacoustic microscopy (MiROM) acquires lipid‐ and protein‐ associated vibrational contrast in intact fat tissue without dyes, preserving native tissue architecture. Through lateral and axial segmentation, MiROM tracks intrinsic intracellular changes during postnatal remodeling. A quantitative spatial analysis tool (Q‐SAT) maps white‐ and
Myeongseop Kim   +7 more
wiley   +1 more source

Sequential Homo‐ and Hetero‐Coupling of Isocyanide and Carbon Monoxide Mediated by Acyclic Imino(silyl)Silylene

open access: yesAngewandte Chemie, EarlyView.
We demonstrate the sequential reactions between an imino(hypersilyl)silylene and aryl isocyanide or carbon monoxide as a molecular‐level model of the Fischer–Tropsch process, providing systematic and detailed insight into C–C bond formation during the homologation of C1 building blocks.
Huaiyuan Zhu   +3 more
wiley   +2 more sources

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