Results 81 to 90 of about 111,163 (223)

Myocardial inflammation is associated with impaired mitochondrial oxidative capacity in ischaemic cardiomyopathy

open access: yesESC Heart Failure, Volume 12, Issue 2, Page 1246-1255, April 2025.
Abstract Aims Myocardial inflammation and impaired mitochondrial oxidative capacity are hallmarks of heart failure (HF) pathophysiology. The extent of myocardial inflammation in patients suffering from ischaemic cardiomyopathy (ICM) or dilated cardiomyopathy (DCM) and its association with mitochondrial energy metabolism are unknown.
Julius Borger   +15 more
wiley   +1 more source

Improving genetic diagnosis of hereditary tumor syndromes: From expanded gene panels to functional genomics

open access: yesInternational Journal of Cancer, EarlyView.
Abstract Genetic tumor risk syndromes (genturis) contribute substantially to the overall cancer burden and provide opportunities for early detection, prevention, and individualized treatment. Yet, many affected individuals remain undiagnosed due to restrictive testing criteria and challenges in variant interpretation.
Mayra Sauer   +11 more
wiley   +1 more source

Oxaliplatin‐induced neuropathy after total neoadjuvant therapy for rectal cancer: Dose–response relationship and impact on quality of life

open access: yesInternational Journal of Cancer, EarlyView.
What's New? Oxaliplatin serves a key role in the treatment of rectal cancer, though it is a significant cause of chemotherapy‐induced peripheral neuropathy. As total neoadjuvant therapy, in which all therapy is given before surgery, has become more common, understanding neuropathy has grown increasingly important. This study examined neuropathy and its
Georg W. Wurschi   +29 more
wiley   +1 more source

Seidl E., Römisches Privatrecht

open access: yesCzasopismo Prawno-Historyczne, 1966
Recenzja: E. Seidl, Römisches Privatrecht, Köln—Berlin—München 1963, ss. XII+262.
Wiesław Litewski
doaj  

Prediction of dose reductions and impact of reduced starting doses of CDK4/6i on effectiveness in HR‐positive/HER2‐negative metastatic breast cancer: Real‐world data from the OPAL registry

open access: yesInternational Journal of Cancer, EarlyView.
What's New? Balancing efficacy and tolerability is challenging in oncology, as standard dosing often prioritizes maximum tolerated doses over other patient needs. Here, the authors developed a predictive index to identify patients with increased probability of dose reduction in metastatic breast cancer and compared the real‐world effectiveness of ...
Patrick Marschner   +19 more
wiley   +1 more source

Reinhold Zippelius: Juristische Methodenlehre

open access: yesČasopis pro Právní Vědu a Praxi, 2002
Recenze publikace - Reinhold Zippelius: Juristische Methodenlehre C. H. Beck, München, 7. přeprac. vyd., 1999, 120 str.
Jan Kysela
doaj  

I Can't Split Myself in Two (or Five): Job Crafting in Highly Demanding and Interdependent Work Environments

open access: yesJournal of Organizational Behavior, EarlyView.
ABSTRACT Employees in highly demanding, interdependent work environments face a dilemma: while avoidance‐focused job crafting can preserve their own well‐being, these self‐initiated changes to their jobs could negatively affect coworkers. Drawing on qualitative interviews with 81 employees concurrently working for multiple agile teams in a European ...
Helene Tenzer   +4 more
wiley   +1 more source

Indirect effects of Seeking Safety plus sertraline on alcohol use: The mediating role of reductions in posttraumatic stress disorder symptom severity

open access: yesJournal of Traumatic Stress, EarlyView.
Abstract Posttraumatic stress disorder (PTSD) symptoms and alcohol use frequently co‐occur and are mutually reinforcing. Few studies have examined how changes in PTSD severity influence subsequent changes in alcohol use, particularly in the context of comorbidity treatments. This secondary analysis utilized data from a clinical trial comparing 12 weeks
Lesia M. Ruglass   +11 more
wiley   +1 more source

Paradigmata vědy o výchově

open access: yesPedagogická Orientace, 2018
Adorno, Th. W. u. a.: Der Positivismusstreit in der deutschen Soziologie, Neuwied/Berlin 1972. Ders.: Negative Dialektik, Frankfurt/M. 1966. Albert, H.: Positivismus — Kritischer Rationalismus. In: Wulf, Ch.
Christoph Wulf
doaj  

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