Results 121 to 130 of about 4,832,032 (261)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Smoking Cessation Apps for People with Schizophrenia: How Feasible Are m-Health Approaches? [PDF]

Behav Sci (Basel), 2022
Sawyer C, Hassan L, Guinart D, Agulleiro LM, Firth J.   +4 more
europepmc   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

E-Health and M-Health in Obesity Management: A Systematic Review and Meta-Analysis of RCTs. [PDF]

Nutrients
Chiavarini M, Giacchetta I, Rosignoli P, Fabiani R.   +3 more
europepmc   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Five years of app evaluation: Insights from a framework in practice - a systematic review on the m-health index and navigation database. [PDF]

Internet Interv
Herpertz J, Dwyer B, Wagner E, Mikkelson J, Opel N, Torous J.   +5 more
europepmc   +1 more source

Evaluation of Usability and User Experience of Oncodoc 's M-Health Application for Early Detection of Cancer. [PDF]

Asian Pac J Cancer Prev, 2022
Wulandari R, Pangarsa EA, Andono PN, Rachmani E, Sidiq M, Setyowati M, Waluyo DE.   +6 more
europepmc   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Caregiver and Patient Input for Quality and Safety (C-PIQS) Pilot Study: Patient-Initiated Safety Observations Using an m-Health Tool. [PDF]

J Patient Saf
Sharma AE, Avina L, Tran A, Boscardin J, Sosa MC, Garcia M, Solis S, Sarkar U, Rosenbluth G, Stafford M, Harrison JD, Auerbach A, Bardach NS.   +12 more
europepmc   +1 more source