Results 161 to 170 of about 1,003,978 (336)

Brainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel   +8 more
wiley   +1 more source

New technologies and education in the field of cultural heritage. «Madrid Industrial, Itineraries». An example of m-learning applied to industrial heritage

open access: yesTecnología, Ciencia y Educación, 2015
The development of the information and communication technologies (ICT), integrated within the current knowledge society, has transformed the way in which the human being relates to its environment. The integration of internet on mobile devices is one of
Francisco David de la Peña Esteban   +2 more
doaj  

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang   +6 more
wiley   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende   +26 more
wiley   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett   +8 more
wiley   +1 more source

Development of ODL in a Newly Industrialized Country according to Face-to-Face Contact, ICT, and E-Readiness

open access: yesInternational Review of Research in Open and Distributed Learning, 2013
A large number of unqualified and under-qualified in-service teachers are holding back socio-economical development in South Africa, a newly industrialized country.
J. Marinda van Zyl   +2 more
doaj  

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina   +11 more
wiley   +1 more source

Mobile VLE vs. Mobile PLE: How Informal is Mobile Learning?

open access: yes
Mobile Learning Systems are often described as supporting informal learning; as such they are a good fit to the idea of Personal Learning Environments (PLEs), software systems that users choose and tailor to fit their own learning preferences. This paper
Chen, Wen-Pin   +2 more
core  

Context-Aware Adaptive System For M- Learning Personalization

open access: yes, 2014
International audienceContext-aware mobile learning is becoming important because of the dynamic and continually changing learning settings in learner's mobile environment, giving rise to many different learning contexts that are difficult to apprehend ...
Mendes, Florence   +2 more
core   +1 more source

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