Results 221 to 230 of about 28,693,335 (281)

Successful Percutaneous Retrieval of an Embolized MitraClip From the Right Subclavian Artery. [PDF]

Catheter Cardiovasc Interv
Aalaei-Andabili SH, Chahal DS, Savadkohi ST.   +2 more
europepmc   +1 more source

Pharmacokinetic and pharmacodynamic interaction of enavogliflozin, a sodium‐glucose cotransporter 2 inhibitor, with glimepiride and metformin in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aims Enavogliflozin, a sodium‐glucose cotransporter 2 inhibitor, is expected to be coadministered with antihyperglycaemic drugs with different mechanisms of action. This study aimed to investigate the pharmacokinetic (PK) and pharmacodynamic (PD) interactions between enavogliflozin, glimepiride and metformin.
Kyungrin Chang, Yoonjin Kim, Daye Jung, Jae Min Cho, Joo‐Youn Cho, SeungHwan Lee   +5 more
wiley   +1 more source

Assessment of epithelial barrier integrity in cellular monolayer models using low cost, clinically approved fluorescent contrast agents. [PDF]

PLoS One
Monfort Sanchez E, Watson AF, Haider T, Chrysostomou D, Storder M, Mandal N, Kelly P, Marchesi JR, Avery J, Bourke CD, Thompson AJ.   +10 more
europepmc   +1 more source

Rocavorexant, a novel, selective orexin‐1 receptor antagonist: Safety, tolerability and pharmacokinetics in healthy adults and individuals with opioid use disorder

British Journal of Clinical Pharmacology, EarlyView.
Aims Rocavorexant (INDV‐2000), a selective orexin‐1 receptor antagonist, reduces drug self‐administration and anxiety in nonclinical studies. This Phase 1 programme evaluated the safety, pharmacokinetics and pharmacodynamics of rocavorexant in healthy volunteers and treatment‐seeking individuals with opioid use disorder (OUD).
Martin Kankam, Rana Al‐Awam, Rajinder Shiwach, Andrew S. Huhn, Malcolm A. Young, Robert L. Dobbins   +5 more
wiley   +1 more source

Influence of age, frailty and non-cardiac comorbidities on survival in patients undergoing mitral valve edge-to-edge repair - a perspective from the German health care system. [PDF]

Int J Cardiol Heart Vasc
Piayda K, Keweloh N, Unsöld B, Sossalla S, Polzin A, Voss F, Haschemi J, Giemsa M, Marschall U, Hennig B, Beil M, Kelm M, Jung C.   +12 more
europepmc   +1 more source

Pharmacokinetics, efficacy and safety of dupilumab administered with prefilled pen devices in patients aged <12 years with atopic dermatitis

British Journal of Clinical Pharmacology, EarlyView.
Aim For children with atopic dermatitis (AD), dupilumab is available as a prefilled syringe (PFS) from the age of 6 months and as a prefilled pen (PFP) for patients aged ≥2 years, in 200‐ and 300‐mg devices. This substudy of an ongoing open‐label extension study evaluated the pharmacokinetics, efficacy and safety of switching from a dupilumab PFS ...
Amy S. Paller, Elaine C. Siegfried, Ashish Bansal, Jing Xiao, Faisal A. Khokhar, Michael Van Spall, Xia Liu, Christine Xu, Ariane Dubost‐Brama, Matthew P. Kosloski   +9 more
wiley   +1 more source

Static or microfluidic? A comparative pilot study of an <i>in vivo-in vitro</i> validated human iPSC-derived blood-brain barrier model for neurotoxicity hazard assessment. [PDF]

NAM J
Kurtenbach P, Hahn M, Thevis M, Lamshöft M.   +3 more
europepmc   +1 more source

Flexible working and professional relationships in schools: An ecological approach

British Educational Research Journal, EarlyView.
Abstract In English schools, the policy environment has recently moved considerably in favour of teachers taking planning, preparation and assessment (PPA) time away from the school site as one approach to flexible working in support of teacher retention.
Victoria Cook, Lisa‐Maria Müller, Becky Taylor, Hester Burn   +3 more
wiley   +1 more source

Tricuspid Regurgitation, the Once-Forgotten Valve: Current Management Options and Remaining Gaps After the 2025 European Society of Cardiology Guidelines Update. [PDF]

Rev Cardiovasc Med
Cafaro A, Tahoun A, Mussardo M, Mandurino-Mirizzi A, Quarta L, Rizzo F, Tondo A, Iacovelli F, Fischetti D, Colonna G.   +9 more
europepmc   +1 more source