Results 201 to 210 of about 946,279 (310)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Correction to "COCOMO2: A Coarse-Grained Model for Interacting Folded and Disordered Proteins". [PDF]

J Chem Theory Comput
Jussupow A, Bartley D, Lapidus LJ, Feig M.   +3 more
europepmc   +1 more source

Exceptional Field Theory. I. E[subscript 6(6)]-Covariant Form of M-Theory and Type IIB

, 2014
Olaf Hohm, Henning Samtleben
openalex   +1 more source

M-theory realization of a an N = 1 supersymmetric chiral gauge theory in four dimensions [PDF]

, 1999
Jaemo Park
openalex   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Permanent electrostatic moments through the lens of atoms: assessing variational Hirshfeld methods. [PDF]

RSC Adv
van Zyl M, Castillo-Orellana C, Pujal L, Heidar-Zadeh F.   +3 more
europepmc   +1 more source

11D Supergravity as a gauge theory for the M-algebra [PDF]

, 2005
Mokhtar Hassaı̈ne, Ricardo Troncoso, Jorge Zanelli   +2 more
openalex   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Manual wheelchair training for individuals with chronic and progressive conditions: a critical realist approach to improving practice. [PDF]

BMC Health Serv Res
Charlton K, Murray C, Layton N, Attrill S.   +3 more
europepmc   +1 more source

Topological K-theory of the group C*-algebra of a semi-direct product\n Z^n rtimes Z/m for a free conjugation action [PDF]

, 2011
Martin Langer, Wolfgang Lueck
openalex   +1 more source