Molecular Oncology, EarlyView.The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh +6 more
wiley +1 more source
Journal of Applied Clinical Medical Physics, Volume 23, Issue 12, December 2022., 2022 Abstract Purpose To assess whether the joint application of hybrid iterative reconstruction (HIR) and an adaptive filter (AF) could reduce streak artifacts and improve image quality of neck‐and‐shoulder computed tomography (CT). Methods This study included 96 patients with suspicious neck lesions who underwent a routine nonenhanced scan on a 64‐slice ...
Wenfeng Jin +6 more
wiley +1 more source
Discussion: “Theory of Nonequilibrium Thermodynamics With Application to the Transport Processes in a Solid” (El-Saden, M. R., 1966, ASME J. Heat Transfer, 88, pp. 57–61) [PDF]
, 1966 J. M. Honig
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Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer
Molecular Oncology, EarlyView.We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi +26 more
wiley +1 more source
The variational theory of geodesies by M. M. Postnikov. Translated from the Russian by Scripta Technica Inc. edited by Bernard R. Gelbaum. W.B. Saunders Company, Philadelphia and London, 1967. viii + 200 pages. [PDF]
, 1968 Hanno Rund
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Molecular Oncology, EarlyView.Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé +7 more
wiley +1 more source
Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM
Molecular Oncology, EarlyView.CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak +14 more
wiley +1 more source
XXXI. An abstract of the essential principles of M. Cauchy's view of the undulatory theory, leading to an explanation of the dispersion of light; with remarks [PDF]
Banen Powell
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Introduction to the theory of algebraic functions and numbers, by M. Eichler. Academic Press, New York and London, 1966. xiv + 324 pages. U.S. $14.50. [PDF]
, 1969 A. Trojar
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Molecular Oncology, EarlyView.This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini +10 more
wiley +1 more source