Results 121 to 130 of about 284,413 (281)

Soft‐Drug‐Inspired MnSTF Nano‐Adjuvant for Safe and Synergistic cGAS–STING Activation in Tumor Immunotherapy

Advanced Science, EarlyView.
This study introduces MnSTF, a soft‐drug‐inspired nanoadjuvant that overcomes the systemic toxicity of STING agonists. Through Mn2+ coordination with an ENPP1 inhibitor, it enables safe cGAS‐STING activation, remodels the tumor immune microenvironment, and synergizes with radiotherapy or vaccines to elicit robust antitumor immunity.
Guangfei Sun, Jiancheng Pan, Rui Li, Ruoxi Li, Ziyan Liu, Jinhui Wu, Tingsheng Lin, Yiqiao Hu, Ahu Yuan   +8 more
wiley   +1 more source

Três perspectivas gestuais para uma performance percussiva: técnica, interpretativa e expressiva Three gestural perspectives for a percussive performance: technical, interpretative and expressive

Per Musi, 2013
Esse artigo¹ propõe uma reflexão sobre a atuação do intérprete percussionista em função dos gestos que o mesmo poderá aplicar sobre uma performance musical.
Fernando Chaib
doaj  

Alkaline Phosphatase‐Activated NIR‐II AIEgens Nanosystem for Surgical and Postoperative Closed‐Loop Therapy of Advanced Osteosarcoma

Advanced Science, EarlyView.
This study designed a tumor microenvironment‐responsive AIEgen nanoparticle for near‐infrared photoimmunotherapy, which inhibits primary tumors and metastasis by promoting pyroptosis and suppressing aerobic glycolysis. ABSTRACT In advanced osteosarcoma, tumor invasion often prevents complete resection, and immunotherapy is limited by the tumor's ...
Kaiyuan Liu, Ruotong Li, Li Zhang, Hengli Lu, Binhui Yang, Qian Hu, Yining Tao, Haoran Mu, Jing Han, Pengfei Zan, Jiakang Shen, Dongqing Zuo, Hongsheng Wang, Wei Sun, Xingjun Zhu   +14 more
wiley   +1 more source

"Você mandou eu cantar, na mente que eu não sabia": estruturação formal e camuflagem em um gênero musical camponês do médio Jequitinhonha "Você mandou eu cantar, na mente que eu não sabia": formal structuring and camouflage in a peasant musical genre from the mid Jequitinhonha river (south-east of Brazil)

Per Musi, 2013
O paulista é um importante gênero músico-coreográfico camponês no médio Jequitinhonha (Minas Gerais). A partir da análise formal de alguns de seus parâmetros técnicos, este artigo busca explorar mecanismos através dos quais uma forma musical e literária ...
Leonardo Pires Rosse
doaj  

Early Radial Extracorporeal Shockwave Stimulation on Proximal Tibial Circular Osteotomy Site Enhanced Heterotopic Skin Wound Healing via Small Extracellular Vesicles

Advanced Science, EarlyView.
A schematic diagram of the mechanism where small extracellular vesicles mediate the enhancement of heterotopic wound healing by radial extracorporeal shockwave stimulation at a proximal tibial osteotomy site. ABSTRACT Wound healing represents a complex biological process necessitating innovative therapeutic approaches, particularly for chronic wounds ...
Xiaoping Xie, Songqi Bi, Bang Su, Rongqi Zhou, Xudong Li, Zhixing Yan, Xiaoyang Zhou, Fanxu Wang, Tiecheng Yu   +8 more
wiley   +1 more source

Convenções e invenções em torno da tópica 5 - #5 - 6 no processo musical nacionalista no Brasil

Per Musi, 2014
Este artigo tem por objetivo averiguar o processo de consolidação da tópica 5 - #5 - 6 na música brasileira, bem como seu uso como elemento de significação nacionalista em canções de compositores como Pixinguinha, Ary Barroso e Gonzaguinha, buscando ...
George Manoel Farias
doaj  

SMart Nanoparticle–Hydrogel Hybrid System for Synergistic Eradication of Infection and Promotion of Wound Healing

Advanced Science, EarlyView.
The integrated system, comprising bacterial‐targeted photothermal nanoparticles (Fe2O3‐CS@RBP) and multifunctional hydrogels (PAOC‐3@BA) modules, achieves rapid wound healing within one week. This work introduces a smart therapeutic platform that integrates bacterial targeting, self‐regulating photothermal therapy, tissue adhesion, and stimulus ...
Hongping Wan, Huirong Tan, Xinghong Zhao
wiley   +1 more source

Brownfields in the Czech Republic in connection with historical centers [PDF]

, 2019
Předmětem zadání Diplomová práce je urbanistická studie na území v části bývalé Tepny v Náchodě. Areál Tepny je z velké části již po demolici a v současné době chátrá.
Murárová, Lucia
core  

Single‐Cell Mitochondrial Lineage Tracing Decodes Fate Decision and Spatial Clonal Architecture in Human Hematopoietic Organoids

Advanced Science, EarlyView.
This study repurposes mitochondrial DNA mutations as endogenous barcodes for lineage tracing in human pluripotent stem cell‐derived organoids. Integrated with transcriptomic and spatial data, it reveals NOTCH‐mediated stromal‐progenitor crosstalk orchestrates clonal dynamics and spatial zonation during early hematopoietic development, offering a non ...
Yan Xue, Junhao Su, Yiming Chao, Lu Liu, Xinyi Lin, Yang Xiang, Mun Kay Ho, Zezhuo Su, Junyi Chen, Zhuojuan Luo, Chengqi Lin, Ruibang Luo, Theo Aurich, Jianfeng Wu, Kelvin Sin Chi Cheung, Yuanhua Huang, Joshua W. K. Ho, Ryohichi Sugimura   +17 more
wiley   +1 more source

Marta Saré de Edu Lobo: memórias híbridas

Per Musi, 2014
Nos anos de 1960, Edu Lobo era reconhecido pela preocupação estética e social em sua música. Os elementos para elaboração destas composições eram oriundos da música nordestina, da bossa nova e posteriormente da música "erudita".
Everson Ribeiro Bastos, Adriana Fernandes   +1 more
doaj