Results 131 to 140 of about 39,426 (199)

Comparison of Model‐Predicted and Observed Evinacumab Pharmacokinetics and Efficacy in Children Aged < 5 Years With Homozygous Familial Hypercholesterolemia

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Evinacumab, an angiopoietin‐like 3 inhibitor, significantly reduces low‐density lipoprotein cholesterol (LDL‐C) in patients with homozygous familial hypercholesterolemia (HoFH). Herein, we report pharmacokinetic and efficacy analyses of evinacumab in < 5‐year‐old patients with HoFH.
Sébastien Bihorel, Robert Dingman, Jeanne Mendell, Katy C. Norman, Richard T. George, Xue‐Qiao Zhao, Robert Pordy, Daniel Garcia, Wendy S. Putnam, Geetha Raghuveer, Brian W. McCrindle, Elena Fornari, Ivo Baric, Shubha Srinivasan, Melissa Diamond, Eliot A. Brinton, John D. Davis, A. Thomas DiCioccio, Lutz Harnisch   +18 more
wiley   +1 more source

REVIEW | Hip-Hop in Europe: Cultural Identities and Transnational Flows [PDF]

IASPM Journal, 2016
James Cox
doaj   +1 more source

Mediating Effects of Sleep Problems and Emotional Symptoms in the Relationship Between Chronotype and Self-Harm Among Adolescents Aged 11-19 Years. [PDF]

Psychol Res Behav Manag
Zou Y, Yan G, Li M, Dai X, Hou X, Wang M, Sun L, Yin H, Xu G.   +8 more
europepmc   +1 more source

Founder's entry strategy and funding performance in the crowdfunding industry: The mediating role of founder's attention

Strategic Entrepreneurship Journal, EarlyView.
Abstract Research Summary Building on recent studies on founders' entry strategy and the attention‐based view, our study examines the underexplored relationship between entrepreneurial entry mode and funding performance. We offer a novel perspective on how different entry strategies—such as hybrid, portfolio, and full‐time entrepreneurship—impact start‐
Dalee Yoon, Joon Mahn Lee, Luke Rhee
wiley   +1 more source

Exosome-mediated effects of BRCA1 on cardiovascular artery disease. [PDF]

Cell Biol Toxicol
Yu H, Wei D, Liao W, Shang X, Li D, Liu C, Deng Q, Huangfu H.   +7 more
europepmc   +1 more source

Controlled Nanoconfinement in a Microfluidic Modular Bead Array Device via Elastomeric Diaphragm Collapse for Enhancing Biomolecular Binding Kinetics

Small, EarlyView.
A modular platform for controlled nanoconfinement over a large area is presented using an elastomeric diaphragm integrated with strain sensors and microfabricated posts (≈500 nm) to enhance biomolecular binding by alternating between confinement and bulk transport for rapid DNA immobilization and screening aptamers on their binding affinities to target
Abdullah‐Bin Siddique, Jui‐Hong Weng, Deng‐Kai Yang, Chia‐Fu Chou, Nathan S. Swami   +4 more
wiley   +1 more source

Molecular dynamics, docking and quantum calculations reveal conformational changes influenced by CYP271A amino acid mutations related to cerebrotendinous xanthomatosis. [PDF]

Sci Rep
Sixto-López Y, Mendoza-Figueroa HL, Landeros-Rivera B, Camacho-Molina A, Correa-Basurto J.   +4 more
europepmc   +1 more source

High‐Voltage Cathode Materials for Sodium‐Ion Batteries: Advances and Challenges

Small, EarlyView.
This review explores the role of high‐voltage cathode materials in enhancing the performance of SIBs. It focuses on strategies to improve energy density, rate capacity, and stability, addressing challenges like phase transitions, metal migration, and electrolyte degradation.
Congqi Ren, Yulian Dong, Yong Lei
wiley   +1 more source

Gallic Acid Inhibits the Proliferation and Migration of Ovarian Cancer Cells via Inhibition of the PI3K-AKT Pathway and Promoting M1-Like Macrophage Polarization. [PDF]

Anal Cell Pathol (Amst)
Meng R, Zhang Z.
europepmc   +1 more source

Synergistic Effect of Prolonged Oxygenation and Reactive Oxygen Species Scavenging on Diabetic Wound Healing Using an Injectable Thermoresponsive Hydrogel

Small, EarlyView.
The oxygen‐generating and reactive oxygen species‐scavenging hydrogel (ORH) exhibits thermoresponsive gelation and incorporates oxygen‐generating microspheres(OGMs) and chitosan‐catalase complexes(CSCATs) via hydrophobic and ionic interactions. Upon injection into irregular wound sites, ORH forms a gel at body temperature and sustains the release of ...
Jiyeon Lee, Jun Kim, Jisun kim, Soo‐Chang Song   +3 more
wiley   +1 more source