Results 101 to 110 of about 77,069 (259)

Systemic Therapy for Metastatic Pancreatic Cancer—Current Landscape and Future Directions

open access: yesCurrent Oncology
Pancreatic ductal adenocarcinoma (PDAC) is a significant cause of cancer-associated mortality, with a rising global incidence. A paucity of strong predictive risk factors mean screening programmes are difficult to implement.
Daniel Netto   +5 more
doaj   +1 more source

A Framework for Emergency Department–Integrated Hepatitis C Test‐and‐Treat in the United States

open access: yesJournal of Viral Hepatitis, Volume 33, Issue 6, June 2026.
ABSTRACT Despite the availability of curative, direct‐acting antiviral therapy, hepatitis C virus elimination remains incomplete. Losses across the care cascade continue to limit impact, from initial diagnosis to sustained virologic response. Fewer than 1/3 of individuals ultimately achieve cure. These gaps reflect a delivery system that does not align
Saeed S. Graham
wiley   +1 more source

Identification of selective inhibitors of RET and comparison with current clinical candidates through development and validation of a robust screening cascade [version 2; referees: 4 approved]

open access: yesF1000Research, 2016
RET (REarranged during Transfection) is a receptor tyrosine kinase, which plays pivotal roles in regulating cell survival, differentiation, proliferation, migration and chemotaxis.
Amanda J. Watson   +13 more
doaj   +1 more source

Far-infrared observations of M20 /NGC 6514/

open access: yesThe Astrophysical Journal, 1976
A far-infrared map of M20 shows a total flux of 26 kJy at an effective wavelength of 69 microns and a size of 8 arcmin FWHM. In the region near M20, two compact far-infrared sources were also detected; one source coincides with W28 C, and the other is not identified with any radio source.
E. L. Wright, G. G. Fazio, F. J. Low
openaire   +1 more source

New Q matrices and their functional equations for the eight vertex model at elliptic roots of unity

open access: yes, 2008
The Q matrix invented by Baxter in 1972 to solve the eight vertex model at roots of unity exists for all values of N, the number of sites in the chain, but only for a subset of roots of unity. We show in this paper that a new Q matrix, which has recently
A.V. Razumov   +23 more
core   +1 more source

Crystal Structure and Mutational Analysis of Aminoacylhistidine Dipeptidase from Vibrio alginolyticus Reveal a New Architecture of M20 Metallopeptidases*

open access: yesJournal of Biological Chemistry, 2010
Aminoacylhistidine dipeptidases (PepD, EC 3.4.13.3) belong to the family of M20 metallopeptidases from the metallopeptidase H clan that catalyze a broad range of dipeptide and tripeptide substrates, including l-carnosine and l-homocarnosine ...
Chin-Yuan Chang   +9 more
semanticscholar   +1 more source

Generation cycles in experimental populations of a multivoltine insect

open access: yesJournal of Animal Ecology, Volume 95, Issue 5, Page 782-794, May 2026.
Although theory suggests various mechanisms by which environmental and ecological factors may drive generational fluctuations, our field‐cage experiment is the first to demonstrate how internal dynamics and external disturbances jointly produce synchronised, large‐scale outbreak cycles.
Takehiko Yamanaka   +3 more
wiley   +1 more source

Economic Transformation in the Digital Age: The Nexus Between Learning and Innovation

open access: yesECONOMICS
This research examines the implications of new generation digital learning technologies for the transformation of skill formation and economic outcomes under a now-ubiquitous educational environment.
Pavithra J C, Sundari V Mohana
doaj   +1 more source

Phases of massive gravity

open access: yes, 2004
We systematically study the most general Lorentz-violating graviton mass invariant under three-dimensional Eucledian group using the explicitly covariant language. We find that at general values of mass parameters the massive graviton has six propagating
Dubovsky, S. L.
core   +1 more source

The MdICE1/MdFAMA‐MdTYDC Transcriptional Module Confers Cold Tolerance by Regulating Dopamine Metabolism in Apple

open access: yesPlant Biotechnology Journal, Volume 24, Issue 5, Page 3012-3031, May 2026.
ABSTRACT Low temperature is a critical abiotic stress that imposes major constraints on the sustainable development of the fruit tree industry. Although exogenous dopamine has been shown to enhance cold tolerance in plants, its molecular mechanisms in apple (Malus domestica) remain poorly understood.
Kexin Tan   +9 more
wiley   +1 more source

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