Results 201 to 210 of about 472,912 (287)

Fc‐Dependent Targeting of the GAS6–MERTK Axis With Monoclonal and Bispecific Antibodies Overcomes Drug Resistance Across EGFR Mutations in Exons 19, 20, and 21

Advanced Science, EarlyView.
EGFR mutations drive a substantial fraction of non‐small cell lung cancers (NSCLC) and are effectively targeted by tyrosine kinase inhibitors (TKIs), including osimertinib. However, resistance inevitably develops through secondary mutations and compensatory receptor activation, including the GAS6 receptor MERTK.
Suvendu Giri, Boobash Raj Selvadurai, Nitin Gupta, Arturo Simoni‐Nieves, Alessandro Genna, Moshit Lindzen, Rishita Chatterjee, Marieke Van Daele, Deepthi Ramesh Kumar, Mirie Zerbib, Roni Oren, Isabelle Sophie Meijer, Elisabeth Franziska Wippich, Yahel Avraham, Rony Dahan, Yuya Haga, Laura E. Kilpatrick, Simon Platt, Stephen J. Hill, Lipika R. Pal, Eytan Ruppin, Yasuo Tsutsumi, Eliane Hadas Yardeni, Muhammad Abu Ahmad, Olga Radinsky, Donatella Romaniello, Mattia Lauriola, Angel Porgador, Yosef Yarden   +28 more
wiley   +1 more source

Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks

Advanced Science, EarlyView.
This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun, Shuangyang Li, Zhixu He, Jingyi Xie, Yaxian Luo, Xuankai Fan, Jingyu Zhang, Luying Qin, Lianjie Peng, Tao Qiu, Tian Zhang, Huiming Wang, Mengfei Yu   +12 more
wiley   +1 more source

Effects of Mepiquat Chloride Application Timing and Concentration on Soybean Plant Architecture and Stem Mechanical Properties. [PDF]

Plants (Basel)
Li J, Qu Z, Li X, Du S, Zhou Y, Li B, Dong S.   +6 more
europepmc   +1 more source

Symptom‐Driven Prediction of Chronic Multimorbidity with a Macro–Micro Heterogeneous Graph Neural Network

Advanced Science, EarlyView.
Clinical symptoms offer a window into multimorbidity. A macro‐micro heterogeneous graph neural network integrates clinical records with biomedical knowledge to improve patient‐level symptom‐disease association learning and visit‐level multimorbidity completion.
Yiheng Ye, Miaoru Han, Siqiao Tang, Zongxiang Zhang, Haichen Shen, Bingzhen Sun, Yan Zhang, Xiaodong Chu, Lijuan Deng, Chaoyang Zheng, Qingchun Huang, Kun Bao, Ronghua Zhang, Yong Wang, Fengwei Zhang, Xiaoli Chu   +15 more
wiley   +1 more source

Poloxamer‐Enabled Thermoresponsive Biobased Controlled‐Release Fertilizer for On‐Demand Nutrient Delivery

Advanced Science, EarlyView.
A bio‑based thermoresponsive controlled‑release fertilizer (TRBF) is fabricated by introducing F127 into a castor‑oil‑derived polyurethane coating. Distinct from conventional bio‑based coated fertilizer (BCF), TRBF achieves temperature‑regulated nitrogen release via F127 reversible phase transition, suppressing nutrient leakage at low temperature and ...
Jiahui Liu, Junyin Li, Ziyao Li, Xiangjie Zhao, Fengyan Fang, Yan Liu, Songyuan Wang, Boning Su, Yuanyuan Yao, Bin Gao, Shugang Zhang, Yuechao Yang   +11 more
wiley   +1 more source

Evaluating the Impact of CYP1A2 Inhibition on the Pharmacokinetics of Savolitinib: A Phase 1 Open-Label Study. [PDF]

Pharmacol Res Perspect
Miah K, Reddy J, Sharma P, Igwegbe I, Nelson S, Muldoon C, Goldwater R, Vishwanathan K.   +7 more
europepmc   +1 more source

Mechanism of Direct Acoustic Construction and Gradient Properties Tuning

Advanced Science, EarlyView.
Directed acoustic construction enables omnidirectional gradient tuning of fingerprint‐inspired microstructures. By investigating the DAC mechanisms, diamond particles are found to enhance acoustic physical, mechanical, and chemical effects, promoting acoustic curing and broadening the range of gradient property tuning.
Dandan Wu, Lijuan Zheng, Guang Yao, Zijun Liu, Liyan Luo, Cile Liang, Chengyong Wang   +6 more
wiley   +1 more source

Systematic Scoring Differences in Large Language Model-Based Clinical Benchmarking Reveal Evaluator-Dependent Divergence: Controlled Evaluation Study. [PDF]

JMIR AI
Dinc R, Ardic N.
europepmc   +1 more source

Dramatic Enhancement and Integration of Properties in Pork Belly‐Inspired All‐Biomass Composite Films via Facile, Sustainable, and Controllable Design

Advanced Science, EarlyView.
A pork belly‐inspired all‐biomass composite film was constructed through layer‐by‐layer assembly of cellulose nanofibers (CNFs), gelatin, and graphitized carbon nanosheets (GCNs) via hydrogen bonding and π–π stacking interactions. The excellent mechanical properties, effective thermal management, and outstanding EMI shielding performance of the ...
Junchao Ren, Chenglei Huang, Chengxu Pei, Mengde Huang, Yuanyuan Xu, Chengyu Yu, Hao Nie, Guangbing Zhao, Shijing Song, Hanwu Lei, Fang Wang, Bin Li, Qingfa Zhang   +12 more
wiley   +1 more source