Results 11 to 20 of about 7,205 (185)

Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis

Hepatology, EarlyView., 2022
EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu, Xiude Fan, Megan R. McMullen, Tatsunori Miyata, Adam Kim, Vai Pathak, Jianguo Wu, Le Z. Day, Josiah E. Hardesty, Nicole Welch, Jaividhya Dasarathy, Daniela S. Allende, Arthur J. McCullough, Jon M. Jacobs, Daniel M. Rotroff, Srinivasan Dasarathy, Laura E. Nagy   +16 more
wiley   +1 more source

Dysfunctional Lipid-Induced Secretion of Glucagon-Like Peptide-2(GLP-2), but Not of Incretins Glucagon-Like Peptide-1(GLP-1)/Glucose-Dependent Insulinotropic Polypeptide(GIP), Promotes Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Onset and Progression Through Gut Barrier Disruption and Endotoxemia. [PDF]

MedComm (2020)
MedComm, Volume 7, Issue 4, April 2026.
Musso G, Pinach S, Mella A, De Michieli F, Calabrese A, Trifiro D, Petrangolini G, Cassader M, Mariano F, Gambino R.   +9 more
europepmc   +2 more sources

Combined Serum Biomarkers in Non-Invasive Diagnosis of Non-Alcoholic Steatohepatitis. [PDF]

PLoS ONE, 2015
Non-alcoholic steatoheaptitis (NASH), the critical stage of non-alcoholic fatty liver disease (NAFLD), is of chronic progression and can develop cirrhosis even hepatocellular carcinoma (HCC).
Mei Yang, Dongping Xu, Yuan Liu, Xiaodong Guo, Wenshu Li, Chaonan Guo, Hongping Zhang, Yinjie Gao, Yuanli Mao, Jingmin Zhao   +9 more
doaj   +1 more source

A study of digital transformation and MSMEs performance from a spatial perspective: Evidence from China

Journal of Economics and Management, 2023
Aim/purpose – Not only have micro, small, and medium enterprises (MSMEs) been regarded as a driving force of the national economy, but they have also become important in promoting innovation and entrepreneurship.
Zheng Bing, Yuan Yuqing, Li Huizhuan, Jiang Yihan   +3 more
doaj   +1 more source

Plasma Levels of K18 Fragments Do Not Correlate with Alcoholic Liver Fibrosis

Gut and Liver, 2019
Background/Aims Noninvasive markers of liver fibrosis in alcoholic liver disease (ALD) are crucial to establish early intervention. Previous studies have suggested that plasma levels of cleaved keratin-18 (K18; M30) fragments can predict the severity of ...
Viola Schlossberger, Mathias Worni, Christina Kihm, Matteo Montani, Christian Datz, Jochen Hampe, Felix Stickel   +6 more
doaj   +1 more source

Onset of heart failure determines the hepatic cell death pattern

Annals of Hepatology, 2011
Background and rationale. Acute and chronic heart failure (HF) may affect the liver, but the underlying mechanisms that lead to progressive liver damage are poorly understood.
Kerstin Herzer, Guntje Kneiseler, Lars Peter Bechmann, Felix Post, Martin Schlattjan, Jan-Peter Sowa, Till Neumann, Günter Marggraf, Raimund Erbel, Guido Gerken, Ali Canbay, Christoph Jochum   +11 more
doaj   +1 more source

News Media Brand Equity in a New Media Environment

Economics and Business, 2022
Digitalisation has profoundly altered how media are distributed and audiences consume media information, reshaping the media environment and introducing new competitors to media brands.
Saulite Linda
doaj   +1 more source

Celebrity Endorsement Influence on Destination Image

Naše Gospodarstvo, 2022
Destination image influences the tourist decision-making process, and their intention to visit, revisit and recommend. Therefore, a positive destination image is considered one of the key destination success factors.
Marković Ivana, Radosavljević Gordana, Borisavljević Katarina   +2 more
doaj   +1 more source

The efficacy of serum cell death biomarkers for diagnosing biliary tract cancer

Scientific Reports, 2018
In this study, we determined the efficacy of the cell death biomarker cytokeratin 18 for diagnosing biliary tract cancer (BTC). We recruited 36 patients with BTC (Malignant group) and 45 patients with benign biliary tract disease (Benign group) for this ...
Mitsuru Sugimoto, Kazumichi Abe, Manabu Hayashi, Tadayuki Takagi, Rei Suzuki, Naoki Konno, Hiroyuki Asama, Yuki Sato, Hiroki Irie, Ko Watanabe, Jun Nakamura, Hitomi Kikuchi, Yuichi Waragai, Mika Takasumi, Minami Hashimoto, Takuto Hikichi, Yoshihiro Nozawa, Hiromasa Ohira   +17 more
doaj   +1 more source

Clinical Evaluation of M30 and M65 ELISA Cell Death Assays as Circulating Biomarkers in a Drug-Sensitive Tumor, Testicular Cancer

Neoplasia: An International Journal for Oncology Research, 2008
Circulating full-length and caspase-cleaved cytokeratin 18 (CK18) are considered biomarkers of chemotherapy-induced cell death measured using a combination of the M30 and M65 ELISAs.
Esther C. de Haas, Alessandra di Pietro, Kathryn L. Simpson, Coby Meijer, Albert J.H. Suurmeijer, Lee J. Lancashire, J. Cummings, Steven de Jong, Elisabeth G.E. de Vries, Caroline Dive, Jourik A. Gietema   +10 more
doaj   +1 more source