Results 81 to 90 of about 1,572,659 (339)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

The Effect of Dimple Insole Design on the Plantar Temperature and Pressure in People with Diabetes and in Healthy Individuals

Sensors
An increase in plantar pressure and skin temperature is commonly associated with an increased risk of diabetic foot ulcers. However, the effect of insoles in reducing plantar temperature has not been commonly studied.
Martha Zequera, Alejandro J. Almenar-Arasanz, Javier Alfaro-Santafé, David Allan, Andrés Anaya, Mauricio Cubides, Natalia Rodríguez, Cesar Salazar, Roozbeh Naemi   +8 more
doaj   +1 more source

Low-Complexity QRD-M with Path Eliminations in MIMO-OFDM Systems

Applied Sciences, 2017
The QR decomposition-M algorithm (QRD-M) is a popular signal detector which has similar error performance with maximum likelihood (ML) in multiple input multiple output-orthogonal frequency division multiplexing (MIMO-OFDM) systems.
Jae-Hyun Ro, Jong-Kwang Kim, Young-Hwan You, Hyoung-Kyu Song   +3 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Heisenberg-Limited Adaptive Gradient Estimation for Multiple Observables

PRX Quantum
In quantum mechanics, measuring the expectation value of a general observable has an inherent statistical uncertainty that is quantified by variance or mean squared error of measurement outcome.
Kaito Wada, Naoki Yamamoto, Nobuyuki Yoshioka   +2 more
doaj   +1 more source

Day-ahead and Intraday wind speed forecasting method based on OS-ELM model with CEEMDAN

Journal of Applied Science and Engineering
This paper presents a model for day-ahead and intraday wind speed forecasting, integrating Complete Ensemble Empirical Mode Decomposition with Adaptive Noise (CEEMDAN) and the Online Sequential Extreme Learning Machine (OS-ELM).
Nguyen Thi Hoai Thu, Ngo Van Khanh, Do Xuan Bach   +2 more
doaj   +1 more source

Brown dwarfs in Eddington-inspired Born-Infeld and beyond Horndeski theories

European Physical Journal C: Particles and Fields, 2019
We studied herein the mass and the radius of brown dwarfs predicted by beyond Horndeski (BH) and Eddington-inspired Born-Infeld (EiBI) gravity theories by numerically solving the modified non-relativistic hydrostatic equations of both theories. We used a
A. S. Rosyadi, A. Sulaksono, H. A. Kassim, N. Yusof   +3 more
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Comparisons of the Performances of Estimators of a Bounded Normal Mean Under Squared-Error Loss

Revstat Statistical Journal, 2009
This paper is concerned with the estimation under squared-error loss of a normal mean θ based on X ∼ N (θ, 1) when |θ| ≤ m for a known m > 0. Nine estimators are compared, namely the maximum likelihood estimator (mle), three dominators of the mle ...
Yiping Dou , Constance van Eeden
doaj   +1 more source