Results 41 to 50 of about 1,169,127 (318)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

Using Platelet-Rich Fibrin to Remove Graphite Tattoos May Yield Excellent Long-Term Result

open access: yesCase Reports in Dentistry
Graphite tattoos are rarely reported because they are mainly caused by an accidental injury or habits during childhood that cause a pencil to penetrate the oral mucosa.
Young Joon Cho   +3 more
doaj   +1 more source

A BP Network Control Approach for QoS-Aware MAC in Cloud Robotics [PDF]

open access: yesXibei Gongye Daxue Xuebao, 2018
The basic idea of Cloud Robotics is dynamically uploading the compute-intensive applications to the cloud, which greatly enhances the intelligence of robots for the high processing and parallel ability of cloud.

doaj   +1 more source

DECREASING THE RA COLLISION IMPACT FOR MASSIVE NB-IOT IN 5G WIRELESS NETWORKS

open access: yesJordanian Journal of Computers and Information Technology, 2021
To satisfy the gigantic need for Internet of things (IoT) applications, the third-generation partnership project (3GPP) has revealed the narrowband IoT (NB-IoT) standard. In any case, collisions in the radio access channel of NB-IoT can be extreme due to
Bilal Rabah Al-Doori, Ahmed Zurfi
doaj   +1 more source

A Flexible and Fast Event-Driven Simulator for wireless MAC protocols [PDF]

open access: yes, 1997
Many multiple-access (MAC) protocols have been or are being proposed for wireless networks. As most of these multiple-access protocols are designed for specific applications (such as telephony) and analyzed accordingly, the analysis results can not ...
Havinga, Paul J.M.   +1 more
core   +5 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

On Achievable Rate Region of Multiple Coordinated Multiple Access Channels [PDF]

open access: yes, 2011
Coordination between two or more multiple access channel (MAC) receivers can enlarge the achievable rate region of the whole system. This paper focuses on coordination by sharing the codebooks of the users between the receivers of MACs.
Heliot, Fabién   +2 more
core   +1 more source

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin   +11 more
wiley   +1 more source

Pulmonary and Disseminated Mycobacterium avium Complex Cases Confirmed by Tissue-Direct Polymerase Chain Reaction-Based Nucleic Acid Lateral Flow Immunoassay of Formalin-Fixed Paraffin-Embedded Tissues

open access: yesInfection and Drug Resistance, 2022
Daisuke Fukushi,1 Keigo Murakami,2 Yuji Watanabe,3 Norihiko Sugimoto,4 Hirotsugu Uehara,4 Masafumi Seki5 1Division of Gastroenterology, Tohoku Medical and Pharmaceutical University Hospital, Sendai City, Miyagi, Japan; 2Division of Pathology, Tohoku ...
Fukushi D   +5 more
doaj  

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