Results 71 to 80 of about 58,664 (273)

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, Volume 600, Issue 2, Page 251-266, January 2026.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Primate Swallowing Is Powered by Both Rotation and Contraction of Suprahyoid Muscles

American Journal of Biological Anthropology, Volume 189, Issue 1, January 2026.
ABSTRACT Objectives Swallowing biomechanics in primates and other mammals is poorly understood, and the effect of hyoid descent on swallowing biomechanics lacks experimental interrogation. In macaques, which share similar swallowing kinematics with humans, the base of the tongue and the food bolus are hypothesized to be driven into the oropharynx by a ...
Courtney P. Orsbon, Nicholas J. Gidmark, Callum F. Ross   +2 more
wiley   +1 more source

Seroepidemiology and Molecular Characterization of Hepatitis E Virus in Macaca Mulatta from a Village in Yunnan, China, where Infection with this Virus Is Endemic

Hepatitis Monthly, 2011
Background Hepatitis E virus (HEV) infection is a significant public health concern and has been identified as a zoonotic infection. Objectives Since no reports have characterized the epidemiological and genotypic features of HEV infections in Macaca ...
Fen Huang, Wenhai Yu, Xiuguo Hua, S. Jing, Wei-kun Zeng, Zhanlong He   +5 more
semanticscholar   +1 more source

Postnatal Development of the Perirhinal and Parahippocampal Cortices: A Stereological Study in Macaque Monkeys

Journal of Comparative Neurology, Volume 534, Issue 1, January 2026.
Volumetric data reveal a late maturation of areas 36r and 36c compared to areas 35, TF, and TH, as well as a tendency for superficial layers in areas 36r and 36c to mature earlier than the deep layers. Neuronal soma size exhibits a transient increase at 6 months of age in most subdivisions.
Justine Villard, Loïc J. Chareyron, Pamela Banta Lavenex, David G. Amaral, Pierre Lavenex   +4 more
wiley   +1 more source

Functional Screening of NDUFAF6 Variants in Knockout Cells and Complementary Computational Analysis

Journal of Clinical Laboratory Analysis, Volume 40, Issue 1, January 2026.
We established an ATP‐based functional screening system in NDUFAF6 knockout cells to evaluate the pathogenicity of gene variants associated with mitochondrial dysfunction. Our results highlight the limitations of in silico predictions and underscore the necessity of experimental validation for accurate variant interpretation.
Feng Jiang, Ayumu Sugiura, Yoshihito Kishita, Kohta Nakamura, Xinju Qi, Yuxin Liu, Kei Murayama, Yasushi Okazaki   +7 more
wiley   +1 more source

Molecular Analysis of Two Different MRSA Clones ST188 and ST3268 From Primates (Macaca spp.) in a United States Primate Center

Frontiers in Microbiology, 2018
Methicillin-resistant Staphylococcus aureus (MRSA) were identified in macaques, their environmental facility, and nasal cultures of personnel from the Washington National Primate Research Center [WaNPRC] and included MRSA ST188 SCCmec IV and MRSA ST3268 ...
Marilyn C. Roberts, Andrea T. Feßler, Stefan Monecke, Stefan Monecke, Ralf Ehricht, Ralf Ehricht, David No, Stefan Schwarz   +7 more
doaj   +1 more source

Chronic Colitis, Juvenile Macaca mulatta [PDF]

, 1993
The general body condition of affected animals reflects emaciation and dehydration. These animals have a moderately dilated colon filled with brown or green fluid feces. The colonic mucosa is diffusely thickened and granular (Fig. 90). Areas of the colonic mucosa may have a rugose appearance and small erosions or microulcers may be evident.
Rick R. Adler, Peter F. Moore, Douglas L. Schmucker, Linda J. Lowenstine   +3 more
openaire   +1 more source

Multiple Mitochondrial Dysfunction Syndrome Caused by IBA57 Gene Mutation: A Case Report and Literature Review

Molecular Genetics &Genomic Medicine, Volume 14, Issue 1, January 2026.
We report a novel IBA57 variant in a pediatric case, with pathogenicity confirmed through familial segregation analysis, Sanger sequencing, 3D protein modeling, and evolutionary conservation studies. Mitochondrial complex activity assays demonstrated functional impairment. A comprehensive review of literature further elucidates the genotypic‐phenotypic
Jia Xu, Xin Zhang, Ying Hua, Li Yang, Dongyu Shi, Shiyan Qiu   +5 more
wiley   +1 more source

Novel strains of Campylobacter cause diarrheal outbreak in Rhesus macaques ( Macaca mulatta ) of Kathmandu Valley [PDF]

, 2022
Rajindra Napit, Prajwol Manandhar, Ajit Poudel, Pragun G Rajbhandari, Sarah Watson, Sapana Shakya, Saman Man Pradhan, Ajay Sharma, Ashok Chaudhary, Christine K. Johnson, Jonna A. K. Mazet, Dibesh Karmacharya   +11 more
openalex   +1 more source

Calorie Restriction Attenuates Transcriptional Aging Signatures in White Matter Oligodendrocytes and Immune Cells of the Monkey Brain

Aging Cell, Volume 25, Issue 1, January 2026.
Our single nuclei RNA sequencing data reveal that long‐term calorie restriction in aged rhesus monkeys reduces neuroinflammation and preserves glial metabolism. In oligodendrocytes, calorie restriction attenuates an immune signature and promotes axonal proximity, while reducing a myelin‐laden microglia population.
Ana T. Vitantonio, Christina Dimovasili, Yuchen Liu, Bingtian Ye, Jou‐Hsuan Roxie Lee, Molly Hartigan, Benjamin Bouchard, Madelyn Ray, Bryce Conner, Kelli L. Vaughan, Julie A. Mattison, Tara L. Moore, Chao Zhang, Douglas L. Rosene   +13 more
wiley   +1 more source