Results 71 to 80 of about 86,826 (273)

Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells

Advanced Science, EarlyView.
ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen, Di Lu, Rukang Liang, Weikeng Tan, Erming Zhao, Sihuang Wu, Xintong Li, Yulong Song, Miaojian Wan, Xiaoyuan Xie, Qi Zhang, Qiuli Liu   +11 more
wiley   +1 more source

Intelligent approach to mining cultural tourism potential areas based on YOLOv4: insights from Macau

Journal of Asian Architecture and Building Engineering
Based on historical background and geopolitical factors, Macau is closely related to Portuguese cities; Macau also currently attaches great importance to the creation of a Sino-Portuguese platform and cultural tourism to drive better economic development.
Yile Chen, Lina Yan, Liang Zheng
doaj   +1 more source

Science teacher education in Macau: a critical review

Asia-Pacific Science Education, 2019
In this reviewing paper, a couple of issues concerning school science education in Macau are discussed, including science teacher education, science curriculum reform, and opportunities and challenges for science teachers.
Bing Wei
doaj   +1 more source

Universal Antibody‐Engineered Lipid Nanoparticles Potentiate Chemo‐Immunotherapy Against Triple‐Negative Breast Cancer by Reprogramming Tumor Cell Metabolism

Advanced Science, EarlyView.
A universal ROR1 antibody‐engineered lipid nanoparticle (LNP) is constructed by sequential drug encapsulation and antibody conjugation. The LNP not only enables enhanced chemotherapeutic efficiency by targeting drug delivery and precise localization of deep‐seated tumors through NIR‐II fluorescence imaging, but also remodels immunosuppressive TME ...
Yeneng Dai, Jiaqi Wang, Yu Liu, Guanda Jiao, Yuheng Gu, Yang Liu, Shengyu Fu, Xing Fan, Jialin Li, Ziang Guo, Kam Tong Leung, Lipeng Zhu, Qi Zhao   +12 more
wiley   +1 more source

Seizing the 'Internet Plus' moment in Africa [PDF]

, 2015
https://www.researchgate.net/publication/292762551_Seizing_the_%27Internet_Plus%27_moment_in_AfricaPublished versionPublished ...
Goncalves, Marcus
core  

Adipocyte‐Derived Exosomal miR‐5099 Mitigates M1 Macrophage Polarization and Adipose Inflammation via c‐Met/NF‐κB Axis to Improve Metabolic Health

Advanced Science, EarlyView.
Celastrol upregulates adipocyte‐derived exosomal miR‐5099, suppressing the macrophage c‐Met/NF‐κB axis to mitigate pro‐inflammatory M1 polarization and adipose inflammation. These miR‐5099‐enriched exosomes also act as endocrine signals targeting the liver, muscle, and adipocytes to significantly enhance systemic insulin sensitivity.
Ping Tang, Lixin Tai, Hongxia Xu, Dongliang Zhu, Jiajia Li, Hao Feng, Jinghui Cui, Shuhai Lin, Li‐jun Di, Li Wang   +9 more
wiley   +1 more source

Boosting Photo‐Pyroelectric Effect via Tunable Polarization and Interfacial Defect Engineering

Advanced Science, EarlyView.
This study reports Ba(Ti0.85Zr0.15)O3 nanocatalysts with enhanced polarization and oxygen‐vacancy‐rich interfaces for efficient NIR‐II photo‐pyroelectric therapy. Zr doping boosts the pyroelectric coefficient and accelerates polarization switching, while oxygen vacancies improve photothermal conversion and surface reactivity.
Yanli Huang, Haifen Luo, Jie Yin, Shuai Cao, Gaolei Dong, Zhi Tan, Chunlin Zhao, Peiye Wen, Fengwei Sun, Shan Zhang, Xianzeng Zhang, Yunlu Dai, Zhen Yang, Wei Huang   +13 more
wiley   +1 more source

A Roman Dialogue on Chinese Porcelain between Pope Pius IV and the Portuguese Archbishop, Friar Bartolomeu dos Mártires: 16th-century Chinese porcelain trade, imitations, consumption, and collections

Китаєзнавчі дослідження
This article highlights an extravagant dinner hosted by Pope Pius IV in October 1563 for the Archbishop of Braga, Dominican Friar Bartolomeu dos Mártires, just weeks before the conclusion of the Council of Trento on December 4th.
Ivo Carneiro de Sousa
doaj   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Rigid‐Flexible Coupling Units Enable Robust Large Birefringence

Advanced Science, EarlyView.
A rigid–flexible coupling strategy, combining flexible (S3)2− linear units with rigid (VO4)3− tetrahedra, yields Sr4(VO4)2S3—a robust crystal exhibiting large birefringence (Δn = 0.52@550 nm) and remarkable thermal, air, and water stability. ABSTRACT Birefringent crystals are central to polarization control in laser technologies (e.g., wave plates and ...
Jie Zhou, Yanqiang Li, Ji Qi, Weiqi Huang, Liangmeng Zhu, Zhiyong Bai, Yang Zhou, Junhua Luo, Sangen Zhao   +8 more
wiley   +1 more source