Results 131 to 140 of about 3,609,102 (305)

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Machine Learning Models to Improve the Differentiation Between Benign and Malignant Breast Lesions on Ultrasound: A Multicenter External Validation Study

Cancer Management and Research, 2021
Ling Huo,1,* Yao Tan,2,* Shu Wang,3 Cuizhi Geng,4 Yi Li,5 XiangJun Ma,6 Bin Wang,2 YingJian He,1 Chen Yao,2,7 Tao Ouyang1 1Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Breast Center, Peking University ...
Huo L, Tan Y, Wang S, Geng C, Li Y, Ma X, Wang B, He Y, Yao C, Ouyang T   +9 more
doaj  

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

A Model for Quantifying the Degree of Understanding in Cross-Domain M2M Semantic Communications

IEEE Access
This paper addresses the problem of semantic communications (SemComs) in intelligent machine-to-machine (M2M) applications. Although M2M applications may employ other languages as the communication medium, natural languages are commonly used as the ...
Ricky Yuen-Tan Hou, Gang Liu, Jefferson Fong, Hui Zhang, Seon-Phil Jeong   +4 more
doaj   +1 more source

Security Issues on Machine to Machine Communications

KSII Transactions on Internet and Information Systems, 2012
Machine to machine (M2M) communications is the hottest issue in the standardization and industry area, it is also defined as machine-type communication (MTC) in release 10 of the 3rd Generation Partnership Project (3GPP). Recently, most research have focused on congestion control, sensing, computing, and controlling technologies and resource management
openaire   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Ubiquitous machine-to-machine service networks

ERCIM News, 2009
In the near future, there will be many more embedded devices than there are mobile phones. When these devices are connected to the Internet, many novel kinds of ubiquitous service will be enabled.
Latvakoski, Juhani, Kallio, Johanna
openaire   +3 more sources

TL-PneuNet: a transfer learning-based pneumonia classification framework

Scientific Reports
Pneumonia is a severe respiratory ailment that may be caused by viruses, fungus, and bacteria. Pneumonia causes the accumulation of water, purulent material, or other fluids in the air sacs (alveoli) of the lungs.
Biswajit Tripathy, Shakir Khan, Sujit Bebortta, Ashraf Kamal, Subhranshu Sekhar Tripathy, Mohd Fazil, Abdullah M. Albarrak   +6 more
doaj   +1 more source