Results 41 to 50 of about 1,147,869 (263)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Spatial cognitive behavior of pigeons induced by electrical stimulation in specific marked area

Brain Research Bulletin
Electric stimulation has become an essential neuroscience technique in various research fields ranging from basic research to neural prosthetics, and it is introduced into the spatial cognitive research. This study used electrical stimulation as a cue to
Xinyu Liu, Yexin Zhang, Yongjun Zhu, Xiaomin Qi, Yanna Ping, Dongyun Wang   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Mitigating choice overload: The interactive effects of set size and overall preference revealed by hierarchical drift diffusion modeling and electroencephalography

NeuroImage
Excessive choice can overwhelm cognitive resources and trigger choice overload, yet its neurophysiological basis—particularly the moderating role of overall preference level—remains underexplored.
Xiaoyang Huang, Sihua Xu
doaj   +1 more source

Toward a M2M-Based Internet of Vehicles Framework for Wireless Monitoring Applications

IEEE Access, 2018
The Internet of Vehicles (IoV) has become an attractive research topic in the fields of communication networks and information processing due to its wide range of potential applications, including public transportation management, road traffic ...
Fei Ding, Ruoyu Su, En Tong, Dengyin Zhang, Hongbo Zhu, Mohamed Wahab Mohamed Ismail   +5 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Improving UAV disaster response with DenseNet and AF-RCNN: a framework for accurate emergency spot detection

Cogent Engineering
Unmanned aerial vehicles (UAVs), commonly known as drones, have emerged as valuable tools in disaster response due to their ability to access remote and hard-to-reach areas.
Prasanna Kumar K R, Mallegowda M, Manoj Kumar D P, Swathi H Y, Ananda Babu J   +4 more
doaj   +1 more source

OrMAC: A Hybrid MAC Protocol Using Orthogonal Codes for Channel Access in M2M Networks

Sensors, 2017
This paper proposes a hybrid medium access protocol named orthogonal coded medium access control (OrMAC), which extends the principle of distributed queuing collision avoidance protocol (DQCA) of wireless local area network (WLAN) to delay-sensitive ...
Ethungshan Shitiri, In-Seop Park, Ho-Shin Cho   +2 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source