Results 31 to 40 of about 3,572,550 (313)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

H-ViT: hardware-friendly post-training quantization for efficient vision transformer inference

Autonomous Intelligent Systems
Vision Transformers (ViTs) have achieved state-of-the-art performance on various computer vision tasks. However these models are memory-consuming and computation-intensive, making their deployment and efficient inference on edge devices challenging ...
Jing Liu, Jiaqi Lai, Xiaodong Deng, Caigui Jiang, Nanning Zheng   +4 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Large Scale MRI Collection and Segmentation of Cirrhotic Liver

Scientific Data
Liver cirrhosis represents the end stage of chronic liver disease, characterized by extensive fibrosis and nodular regeneration that significantly increases mortality risk.
Debesh Jha, Onkar Kishor Susladkar, Vandan Gorade, Elif Keles, Matthew Antalek, Deniz Seyithanoglu, Timurhan Cebeci, Halil Ertugrul Aktas, Gulbiz Dagoglu Kartal, Sabahattin Kaymakoglu, Sukru Mehmet Erturk, Yuri Velichko, Daniela P. Ladner, Amir A. Borhani, Alpay Medetalibeyoglu, Gorkem Durak, Ulas Bagci   +16 more
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

A Two‐Stage Questionnaire and Actigraphy Screening for iRBD in a Multicenter Retrospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid‐eye‐movement sleep behavior disorder is a prodromal marker of synucleinopathies. However, most cases remain undiagnosed due to the insufficient predictive value of questionnaires and limited access to confirmatory video‐polysomnography. We assessed a two‐stage screening strategy combining a brief questionnaire on rapid‐
Caleb A. Massimi, Giorgio Ricciardiello Mejia, Andre Metzger, Kang Hyun Ryu, Salonee Marwaha, Eva Grzegorczyk, Li Zhou, Eliana Jacobs, Boris Gilyadov, Claudia Kunney, Liqhwa Ncube, Ankit Parekh, Emmanuel Mignot, Fanny M. Elahi, Joseph Winer, Kathleen Poston, Andreas Brink‐Kjaer, Emmanuel H. During   +17 more
wiley   +1 more source

Partial Large Kernel CNNs for Efficient Super-Resolution

IEEE Access
Recently, in the image super-resolution (SR) domain, Transformers have outperformed Convolution Neural Networks (CNNs) with reduced computational complexity and parameters by modeling long-range dependencies input-dependently.
Dongheon Lee, Seokju Yun, Youngmin Ro
doaj   +1 more source

The National Security Commission on Artificial Intelligence

, 2021
Website documenting the work of the National Security Commission on Artificial Intelligence, including their final report regarding recommendations for advancement and national security related to "artificial intelligence, machine learning, and ...
National Security Commission on Artificial Intelligence (U.S.)
core  

Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane, Valentina Giunchiglia, Michael C. B. David, Magdalena A. Kolanko, William R. Trender, Peter J. Hellyer, Harmeena Kaur, David J. Sharp, Christopher Carswell, Paresh A. Malhotra, Adam Hampshire   +10 more
wiley   +1 more source

Factored space models: towards causality between levels of abstraction

Journal of Causal Inference
Causality plays an important role in understanding intelligent behavior, and there is a wealth of literature on mathematical models for causality, most of which is based on directed acyclic graphs (DAGs).
Garrabrant Scott, Mayer Matthias Georg, Wache Magdalena, Lang Leon, Eisenstat Sam, Dell Holger   +5 more
doaj   +1 more source