Results 41 to 50 of about 7,806,329 (300)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

A Euclidean transformer for fast and stable machine learned force fields

open access: yesNature Communications
Recent years have seen vast progress in the development of machine learned force fields (MLFFs) based on ab-initio reference calculations. Despite achieving low test errors, the reliability of MLFFs in molecular dynamics (MD) simulations is facing ...
J. Thorben Frank   +3 more
doaj   +1 more source

Contour-Aware Polyp Segmentation in Colonoscopy Images Using Detailed Upsampling Encoder-Decoder Networks

open access: yesIEEE Access, 2020
Colorectal cancer has become one of the most common cause of cancer mortality worldwide, with a five-year survival rate of over 50%. Additionally, the potential of some common polyp types to progress to colorectal cancer is considered high.
Ngoc-Quang Nguyen   +2 more
doaj   +1 more source

Teleconnection Patterns of Different El Niño Types Revealed by Climate Network Curvature

open access: yesGeophysical Research Letters, 2022
The diversity of El Niño events is commonly described by two distinct flavors, the Eastern Pacific (EP) and Central Pacific (CP) type. While the remote impacts, that is, teleconnections, of EP and CP events have been studied for different regions ...
Felix M. Strnad   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Towards a Theory of Representation Learning for Reinforcement Learning

open access: yes, 2021
Presented online via Bluejeans Events on September 15, 2021 at 12:15 p.m.Alekh Agarwal is a researcher who works on theoretical foundations of machine learning, spanning many areas including large-scale and distributed optimization, high-dimensional ...
Agarwal, Alekh
core  

Monitoring the lactation-related behaviors of sows and their piglets in farrowing crates using deep learning

open access: yesFrontiers in Animal Science
Pig farming is a major sector of livestock production. The preweaning stage is a critical period in the pig farming process, where lactation-related behaviors between sows and their piglets directly influence the preweaning survivability of the piglets ...
Yu-Jung Tsai   +7 more
doaj   +1 more source

Is Machine Learning Real Learning?

open access: yesCenter for Educational Policy Studies Journal, 2019
The question of whether machine learning is real learning is ambiguous, because the term “real learning” can be understood in two different ways. Firstly, it can be understood as learning that actually exists and is, as such, opposed to something that only appears to be learning, or is misleadingly called learning despite being something else ...
openaire   +5 more sources

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

Learning curves for decision making in supervised machine learning: a survey

open access: yes
Learning curves are a concept from social sciences that has been adopted in the context of machine learning to assess the performance of a learning algorithm with respect to a certain resource, e.g., the number of training examples or the number of ...
van Rijn J.N., Mohr F.
core   +1 more source

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