Results 61 to 70 of about 3,141,828 (240)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

A Reliability Statistical Evaluation Method of CNC Machine Tools Considering the Mission and Load Profile

IEEE Access, 2019
Reliability of the CNC machine tool (abbreviated as machine tool) relates to the product's reliability and has great influence on the manufacturing process.
Zongyi Mu, Genbao Zhang, Yan Ran, Shengyong Zhang, Jian Li   +4 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Machine performance degradation assessment and remaining useful life prediction using proportional hazard model and SVM [PDF]

This paper proposes a three-stage method involved system identification techniques, proportional hazard model, and support vector machine for assessing the machine health degradation and forecasting the machine remaining useful life (RUL).
Tran, Van Tung
core   +3 more sources

Research on reliability comprehensive evaluation method of five-axis CNC machine tools based on AHP and extension theory

The Journal of Engineering, 2019
Currently, some five-axis CNC machine tools have almost achieved the same advanced level of the western countries in terms of functionality and performance. However, the reliability of system is much lower than similar foreign products.
Pengjia Wang, Hongjun Wang, Xiumei Chen
doaj   +1 more source

Reliability analysis of two-unit cold standby repairable systems under Poisson shock. [PDF]

, 2011
This paper analyses the reliability of a cold standby system consisting of two re- pairable units, a switch and a repairman. At any time, one of the two units is operating while the other is on cold standby.
Shaomin Wu, Wu, Shaomin, Qingtai Wu, Wu, Qingtai   +3 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Dynamic Scheduling and Preventive Maintenance in Small-Batch Production: A Flexible Control Approach for Maximising Machine Reliability and Minimising Delays

Applied Sciences
Single- and small-batch production requires flexible production control to maximise machine reliability and minimise delivery delays. Existing planning approaches often do not take into account the dynamic production conditions of these environments ...
Alexandra Maierhofer, Sebastian Trojahn, Frank Ryll   +2 more
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Sidney Machine Tool Company lathe photograph

This photograph shows a lathe at the Sidney Machine Tool Company. Sidney Tool Company was founded in 1905 by Alfred C. Getz in Sidney, Ohio. Getz was also acting plant manager for Monarch Machine Tool, also in Sidney, during the same time.
Sidney Machine Tool Company
core   +2 more sources