Results 171 to 180 of about 397,477 (259)

Targeting GRP78 and the Proteostasis Network to Break the Therapeutic Ceiling in Neuroendocrine Prostate Cancer

iNew Medicine, EarlyView.
ABSTRACT HSPA5 (also known as GRP78/BiP) is a master regulator of the endoplasmic reticulum (ER) stress response and a key node in the proteostasis network. In neuroendocrine prostate cancer (NEPC), an aggressive, therapy‐refractory lineage that emerges under pressure from androgen receptor (AR) directed therapies, GRP78 is upregulated and co‐opted to ...
Amos Olalekan Akinyemi, Md Rakibul Alam, Mithu Howlader, Mohammad Esfini Farahani, Lixiang Gu, Chun Li, Chripus Ngule, Kevin Fulp, Bolaji Owoyemi, Xinyi Wang, Samuel Nwadialo, Fatemeh Selani, Makumba Esoe, Obaleye Oluwafunminiyi, Zhiguo Li   +14 more
wiley   +1 more source

Definition of Skills and Roles of the Digestive Endoscopy Nurse: Italian Consensus of ANOTE-ANIGEA. [PDF]

Gastroenterol Nurs
Napolitano D, Candela ML, Gaggiotti M, Turchini L, Bertaglia G, Minenna AN, Valdinoci M, Iannone T, Munno N, Iori G, Giaquinto A, Guarini A, Petrocelli G, Zullo A.   +13 more
europepmc   +1 more source

Organoids and organ‐on‐a‐chip models for investigating the pathophysiology of the human reproductive system

Interdisciplinary Medicine, EarlyView.
Organoids and organ‐on‐a‐chips are advancing reproductive system research. In the female reproductive system, applications include cancer organoid models, placental chips, and hormone simulation models. For the male reproductive system, research focuses on drug resistance mechanisms, co‐culture platforms, and infertility studies. These refined in vitro
Hongqi Zhang, Shiwen Deng, Fangfang Jin, Jiayao Qu, Xiang Fan, Peng Chen, Xinrong Fan   +6 more
wiley   +1 more source

Advanced Numerical Modeling of Powder Bed Fusion: From Physics-Based Simulations to AI-Augmented Digital Twins. [PDF]

Materials (Basel)
Łach Ł, Svyetlichnyy D.
europepmc   +1 more source

A Label‐Free Hyperspectral Imaging Device for Ex Vivo Characterization and Grading of Meningioma Tissues

Journal of Biophotonics, EarlyView.
HyperProbe1.1 enables rapid, label‐free biochemical mapping of freshly resected meningiomas. By quantifying endogenous biomarkers such as cytochrome c oxidase, hemoglobin derivatives, and lipids, the system reveals molecular signatures consistent with tumor grading and generates spatial maps that visualize metabolic and vascular heterogeneity across ...
Pietro Ricci, Camilla Bonaudo, Ivan Ezhov, Anam Toaha, Dorotea Nardini, Manuel Camelia, Federica Lucidi, Filippo Nozzoli, Tim Mach, Ilias Tachtsidis, Daniel Rueckert, Alessandro Della Puppa, Luca Giannoni, Francesco S. Pavone   +13 more
wiley   +1 more source

Sarcopenia interventions in long-term care facilities targeting sedentary behaviour and physical inactivity: A systematic review. [PDF]

J Cachexia Sarcopenia Muscle
Mo Y, Chen L, Zhou Y, Bone A, Maddocks M, Evans CJ.   +5 more
europepmc   +1 more source

The Application Value of Transvaginal Three‐Dimensional Ultrasonography in the Diagnosis of Adenomyosis of the Uterus

Journal of Clinical Ultrasound, EarlyView.
In this study, 3D‐TVS measurements of the uterine junction zone (JZ) in 120 patients showed that a JZmax threshold of ≥ 0.45 cm yielded 77% sensitivity and 89% specificity for adenomyosis diagnosis. Notably, JZ thickness varies minimally with age, demonstrating its stability and excellent diagnostic performance.
Mengyu Li, Zhen Zong, Xiaoman Wang, Hebin Zhang   +3 more
wiley   +1 more source

Deep reinforcement learning enhanced PID control for hydraulic servo systems in injection molding machines. [PDF]

Sci Rep
Hao X, Xin Z, Huang W, Wan S, Qiu G, Wang T, Wang Z.   +6 more
europepmc   +1 more source

Electron Microscopy Transfer System to Protect Atmosphere‐Sensitive Materials for Scanning Electron Microscopy Characterization

Microscopy Research and Technique, EarlyView.
SEM–EDX and XRD characterization confirm that pouches made from readily available aluminum foil, used in combination with a commercial cryo‐EM transfer system, effectively protect highly atmosphere‐sensitive and/or hygroscopic materials from contamination during transfer from inert environments to the SEM vacuum chamber.
Louis G. Corcoran, Ellen M. Monzo, Chinomso E. Onuoha, Shivasheesh Varshney, Han Seung Lee, Chris Frethem, Bharat Jalan, Alon V. McCormick, R. Lee Penn   +8 more
wiley   +1 more source

Experimental Investigation of Al₂O₃ Nano-Powder-Mixed Dielectric in EDM-Assisted Micro-Milling. [PDF]

Micromachines (Basel)
Yadav S, Agarwal D, Sharma AK, Singh RK, Chauhan S, Mohanty S.   +5 more
europepmc   +1 more source