Results 61 to 70 of about 95,972 (298)

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Research on the Identification of Some Optimal Threshing and Separation Regimes in the Axial Flow Apparatus

Agriculture, 2023
Starting from the influencing parameters of threshing and separation and implicit seed losses that occur within this process, this paper searched for and identified the optimal threshing regimes to minimize losses depending on the process parameters. The
Nicolae-Valentin Vlăduț, Nicoleta Ungureanu, Sorin-Ştefan Biriş, Iulian Voicea, Florin Nenciu, Iuliana Găgeanu, Dan Cujbescu, Lorena-Diana Popa, Sorin Boruz, Gheorghe Matei, Adam Ekielski, Gabriel-Ciprian Teliban   +11 more
doaj   +1 more source

Turn-to-turn fault protection technique for synchronous machines without additional voltage transformers [PDF]

, 2017
This paper presents a novel protection technique for the detection of inter-turn faults in synchronous machines. It is based on the calculation of voltage in the stator windings from the usual phases and neutral voltage, typically available in ...
Gyftakis, Konstantinos N., Platero , Carlos A., Redondo, Marte   +2 more
core   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Rain Use Efficiency in Southern Romania after Using the Device for Soil Modelling in Interrupted Furrows for Weeding Crops -DMBC-5 [PDF]

E3S Web of Conferences, 2019
The global impact of climate change, with the potential to affect agriculture through changes in temperature, rainwater distribution and amount, leads to the need to develop integrated technologies that increase rain use efficiency and support soil and ...
Oprescu Remus Marius, Voicea Iulian Florin, Dumitru Iulian, Dragan Ioana, Biolan Costel, Ungureanu PNicoleta, Neagu Emil Adrian, Norbert Bara, Jaloba Daniel, Arsenoaia Vlad Nicolae   +9 more
doaj   +1 more source

The small wind turbine field lab extensive field tests for small wind turbines [PDF]

, 2013
This paper describes the research possibilities at the Small Wind Turbine Field Lab and the involved research groups of Ghent University, covering different aspects of a small wind energy system. In contrast to large and medium-sized wind turbines, small
Botteldooren, Dick, De Kooning, Jeroen, De Maeyer, Jeroen, Laveyne, Joannes, Sergeant, Peter, Stockman, Kurt, Van Eetvelde, Greet, Van Paepegem, Wim, Van Wyngene, Karel, Vandevelde, Lieven   +9 more
core  

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Researches on the accumulation and transfer of heavy metals in the soil in tomatoes -Solanum lycopersicum [PDF]

E3S Web of Conferences, 2019
Heavy metals in contaminated soils have benefited from a considerable attention due to the possible risks for the human body. The current study has investigated the accumulation and transfer coefficient for three heavy metals (Cu, Pb, Zn) found in the ...
Niţu Mihaela, Pruteanu Augustina, Bordean Despina Maria, Popescu Carmen, Deak Gyorghy, Boboc Mădălina, Mustăţea Gabriel   +6 more
doaj   +1 more source