Results 101 to 110 of about 4,569,282 (327)
The implementation of uncertainty evaluation model in manufacturability analysis system for miniature machine tool [PDF]
, 2013 The development of Manufacturability Analysis System for micro-machining domain (MicroMAS) is intended to address the need of the 4-axis Miniature Machine Tool (MMT) that require such system to assist the user in generating micro-component through ...
Abdul Shukor, Syaimak
core
Design of an electrochemical micromachining machine [PDF]
, 2014 Electrochemical micromachining (μECM) is a non-conventional machining process based on the phenomenon of electrolysis. μECM became an attractive area of research due to the fact that this process does not create any defective layer after machining and ...
A Muetze +40 more
core +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Part Form Errors Predicted from Machine Tool Performance Measurements [PDF]
, 1997 Machine tool performance testing, as defined by IS0 230 and ANSI B5.54 has been successfully used to maintain and improve the accuracy and repeatability of production-level machine tools.
Farabaugh, F. +3 more
core +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Pembangunan Modul Pengajaran Kendiri (MPK) keusahawanan dalam topik isu keusahawanan bagi pelajar diploma di politeknik [PDF]
, 2004 Terdapat pelbagai kaedah pembelajaran yang telah diperkenalkan termasuklah kaedah pembelajaran yang menggunakan pendekatan pembelajaran bermodul secara kendiri.
Shaik Ismail, Siti Mahani
core
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Application of Type-2 Fuzzy AHP-ARAS for Selecting Optimal WEDM Parameters
Metals, 2020 Machining of the nickel-based alloy is very demanding due to its extreme mechanical properties, for example, higher fatigue strength, better corrosion and creep resistance feature, substantial work hardening capability, and appreciable tensile and shear ...
Binayak Sen +5 more
doaj +1 more source