Results 91 to 100 of about 457,829 (308)

AI and OR in management of operations: history and trends [PDF]

, 2007
The last decade has seen a considerable growth in the use of Artificial Intelligence (AI) for operations management with the aim of finding solutions to problems that are increasing in complexity and scale.
Kobbacy, KAH, Rasmy, MH, Vadera, S
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

A multi-perspective dynamic feature concept in adaptive NC machining of complex freeform surfaces [PDF]

, 2016
This paper presents a new concept of feature for freeform surface machining that defines the changes in feature status during real manufacturing situations which have not been sufficiently addressed by current international standards and previous ...
A Arivazgagan, A Azab, A Banerjee, A Lasemi, CF You, CJ Chiou, EY Heo, F Villeneuve, FP Zhang, G Elber, James Gao, JP Pernot, LH Wang, LH Wang, MR Amin-Naseri, NV Tuong, PJ Nyirenda, RK Gupta, S Gao, SM Amaitik, T Dipper, T Kim, TR Langerak, V Cheutet, V Giri, V Rameshbabu, V Sundararajan, VB Sunil, Xu Liu, YG Li, YG Li, YG Li, YH Chen, Yingguang Li, ZC Chen, ZL Han   +35 more
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Major challenges in prognostics: study on benchmarking prognostic datasets [PDF]

, 2012
Even though prognostics has been defined to be one of the most difficult tasks in Condition Based Maintenance (CBM), many studies have reported promising results in recent years.
Camci, Faith, Eker, Ömer Faruk, Jennions, Ian K.   +2 more
core  

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

CAD feature recognition of machining parts

, 2012
Die Oberflächen von Maschinenteilen lassen sich dank der ständigen Weiterentwicklung der 3D-Scan-Technologie immer schneller erfassen und erzeugen dabei eine Reihe von Punktdaten, die auch Punktwolke genannt werden. Die Entwicklung der Scan-Technologie erfordert effiziente Objekterkennungsprozesse, um die gescannten Maschinenteile mit ihren ...
openaire   +2 more sources

Intelligent systems in manufacturing: current developments and future prospects [PDF]

, 2000
Global competition and rapidly changing customer requirements are demanding increasing changes in manufacturing environments. Enterprises are required to constantly redesign their products and continuously reconfigure their manufacturing systems ...
Kobbacy, KAH, Meziane, F, Proudlove, N, Vadera, S   +3 more
core   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Feature recognition & tool path generation for 5 axis STEP-NC machining of free form / irregular contoured surfaces [PDF]

, 2010
This research paper presents a five step algorithm to generate tool paths for machining Free form / Irregular Contoured Surface(s) (FICS) by adopting STEP-NC (AP-238) format. In the first step, a parametrized CAD model with FICS is created or imported in
Anbalagan, A
core   +1 more source