Results 131 to 140 of about 457,829 (308)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Research on Critical Quality Feature Recognition and Quality Prediction Method of Machining Based on Information Entropy and XGBoost Hyperparameter Optimization

Applied Sciences
To address the problem of predicting machining quality for critical features in the manufacturing process of mechanical products, a method that combines information entropy and XGBoost (version 2.1.1) hyperparameter optimization is proposed.
Dongyue Qu, Chaoyun Gu, Hao Zhang, Wenchao Liang, Yuting Zhang, Yong Zhan   +5 more
doaj   +1 more source

The Integrated Feature-based Modeller - The Completion Step [PDF]

The Integrated Feature-Based Modeller is the kernel of the Integrated Feature-Based Prototype System, developed within a European cooperation between Fraunhofer-IGD, Darmstadt and IMATI, C.N.R., Genova.
Robbiano, Francesco
core  

Online Tool Condition Monitoring Based on Parsimonious Ensemble+

, 2019
Accurate diagnosis of tool wear in metal turning process remains an open challenge for both scientists and industrial practitioners because of inhomogeneities in workpiece material, nonstationary machining settings to suit production requirements, and ...
Dimla, Eric, Lughofer, Edwin, Pedrycz, Witold, Pratama, Mahardhika, Tjahjowidowo, Tegoeh   +4 more
core   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Data Acquisition and Chatter Recognition Based on Multi-Sensor Signals for Blade Whirling Milling

Machines
Bladed components are essential in engines and propulsion systems, but their thin structures, complex geometries, and significant material removal rates during machining make them challenging to manufacture. This study investigates the chatter phenomenon
Xinyu Li, Riliang Liu, Zhiying Zhu
doaj   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Higher Amyloid and Tau Burden Is Associated With Faster Decline on a Digital Cognitive Test

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective A 2‐min digital clock‐drawing test (DCTclock) captures more granular features of the clock‐drawing process than the pencil‐and‐paper clock‐drawing test, revealing more subtle deficits at the preclinical stage of Alzheimer's disease (AD). A previous cross‐sectional study demonstrated that worse DCTclock performance was associated with
Jessie Fanglu Fu, Talia Robinson, Marina Rodriguez Alonso, Adela Francis Malave, Roos J. Jutten, Michael J. Properzi, Brian C. Healy, Jackson C. Thompson, Grace Del Carmen Montenegro, Emma Thibault, Dana Penney, Randall Davis, Reisa A. Sperling, Kathryn V. Papp, Keith A. Johnson, Julie C. Price, Dorene M. Rentz   +16 more
wiley   +1 more source

Tool Wear State Identification Based on the IWOA-VMD Feature Selection Method

Machines
Complex, thin-walled components are the most important load-bearing structures in aircraft equipment. Monitoring the wear status of milling cutters is critical for enhancing the precision and efficiency of thin-walled item machining.
Xing Shui, Zhijun Rong, Binbin Dan, Qiangjian He, Xin Yang   +4 more
doaj   +1 more source

Portable Low‐Field Magnetic Resonance Imaging in People With Human Immunodeficiency Virus

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The aging population of people with HIV (PWH) raises heightened concerns regarding accelerated aging and dementia. Portable, low‐field MRI (LF‐MRI) is an innovative technology that could enhance access and facilitate routine monitoring of PWH.
Annabel Sorby‐Adams, Malachi Keo, Jennifer Guo, Daire Daly, Richard Ahern, Kimon Zachary, Gregory Robbins, Rajesh T. Gandhi, Bragi Sveinsson, Adam de Havenon, Kevin N. Sheth, Otto Rapalino, Juan Eugenio Iglesias Gonzales, W. Taylor Kimberly, Shibani S. Mukerji   +14 more
wiley   +1 more source