Results 141 to 150 of about 13,866,091 (364)
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10
FEBS Open Bio, EarlyView.Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee +6 more
wiley +1 more source
Machine tool vibration is a complex subject requiring a multi-disciplinary approach involving the identification and analysis of the vibration sources and characteristics, as well as its direct and indirect effects. Machine tool vibration is influenced
Widiyarto, Muhammad Helmi Nur
core
Rotor: Jurnal Ilmiah Teknik Mesin, 2016 The optimization technique of machining parameters considering multiple performance characteristics of non conventional machining EDM process using Taguchi method combined with fuzzy logic is presented in this study.
Galang Sandy Prayogo +2 more
doaj
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
MachinesFemtosecond laser machining offers high precision and minimal thermal impact, making it a promising technique for processing hard and brittle materials like single-crystal diamonds (SCDs).
Jiu Yin +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong +3 more
wiley +1 more source
Acute caffeine treatment protects the developing retina from ischemia‐induced cell death
FEBS Open Bio, EarlyView.Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento +6 more
wiley +1 more source
, 2012 The molecular dynamics simulations of nanomachining processes have provided insight into process parameters, material removal and tool wear mechanisms.
Oluwajobi, Akinjide O., Chen, X.
core
Fiber reinforced ceramic matrix composites: from the controlled fabrication to precision machining
International Journal of Extreme ManufacturingFiber reinforced ceramic matrix composites (FRCMCs) are the preferred materials for safety critical components in the fields of aerospace, nuclear engineering, and transportation, with broad market and application prospects.
Shuoshuo Qu +5 more
doaj +1 more source